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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2018; 64(1): 16-24


EFFECT OF CAPICOR ON THE PARKINSON’S DISEASE PATHOGENIC LINKS

I.M. Mankovska1, K.V. Rosova1, O.O. Gonchar1, V.I. Nosar1, L.V. Bratus1, T.I. Drevitska1, I.D. Glazyrin1, N.V. Karasevich2, I.M. Karaban2

  1. O.O.Bogomoletz Institute of Physiology. National Academy of Sciences of Ukraine, Kiev, Ukraine
  2. D.F. Chebotarev Institute of Gerontology National Academy of Medical Sciences of Ukraine, Kiev, Ukraine
DOI: https://doi.org/10.15407/fz64.01.016

Abstract

It was studied the influence of Capicor (containing Meldonium dihydrate and gamma-butyrobetain dihydrate) on the mitochondrial dysfunction and oxidative stress development in humans with Parkinson’s disease. The aim of the present work was to investigate the pro- and antioxidant balance of blood plasma, the morphofunctional state of blood platelets as well as the Parkin gene expression changes in blood leukocytes of patients with Parkinson’s disease before and after Capicor treatment. It was registered the morphological sings of mitochondrial dysfunction (vacuolization, membrane lysis, septiration) in patients with Parkinson’s disease. After Capicor treatment, there was demonstrated a decrease in these destructive changes as well as restructuring of the platelets mitochondrial apparatus (an increase in the mitochondrial number and area, the mitochondrial biogenesis intensification, a rise of autophagy and fusion of mitochondria). These changes are favoring the growth of the energy power of mitochondria. Under the influence of Capicor, there was demonstrated a reduction in oxidative stress expressiveness (a decrease in blood malon dialdehyde content and a rise in blood glutathione peroxidase activity). After Capicor treatment, there was shown the significant increase in the Parkin gene expression in leukocytes of patients with Parkinson’s disease. This increase account for the intensification of the E3-ubiquitin-ligase-substrates proteasomal degradation which are thought to contribute to neuronal cell death.

Keywords: Parkinson’s disease; mitochondria; oxidative stress; Parkin gene; Capicor

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