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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2018; 64(1): 11-15


CARDIOHEMODYNAMIC CHANGES IN FOCAL CEREBRAL ISCHEMIA

R.R. Sharipov, N.A. Dorofeyeva, V.F. Sagach

    O.O.Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz64.01.011

Abstract

To investigate the effect of focal cerebral ischemia on cardiac function, we conducted studies on the rats model of focal cerebral ischemia, isolated occlusion – MCAO. The functional cardiohemodynamic indicators registered using the ultra-miniature catheter 2F (“Millar Instruments”, USA) and Pressure-Volume System. In experiments in vivo, we have been shown that pumping function parameters were decreased: stroke volume and cardiac output decreased by more than 50% during cerebral ischemia. We found diastolic dysfunction of the left ventricle, as evidenced by an increase in 3 times the end-diastolic pressure, a decrease dP/dt min, an increase in 3.8 times the end-diastolic myocardial stiffness. Thus, the focal cerebral ischemia accompanied by diastolic dysfunction and violations of pumping and contractile functions of the heart. Key words: фокальная ишемия головного мозга; церебро- кардиальный синдром; кардиогемодинамика.

Keywords: focal ischemia of the brain; cerebrokardial syndrome; cardioghemmodynamics.

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