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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2018; 64(1): 11-15


R.R. Sharipov, N.A. Dorofeyeva, V.F. Sagach

    O.O.Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine


To investigate the effect of focal cerebral ischemia on cardiac function, we conducted studies on the rats model of focal cerebral ischemia, isolated occlusion – MCAO. The functional cardiohemodynamic indicators registered using the ultra-miniature catheter 2F (“Millar Instruments”, USA) and Pressure-Volume System. In experiments in vivo, we have been shown that pumping function parameters were decreased: stroke volume and cardiac output decreased by more than 50% during cerebral ischemia. We found diastolic dysfunction of the left ventricle, as evidenced by an increase in 3 times the end-diastolic pressure, a decrease dP/dt min, an increase in 3.8 times the end-diastolic myocardial stiffness. Thus, the focal cerebral ischemia accompanied by diastolic dysfunction and violations of pumping and contractile functions of the heart. Key words: фокальная ишемия головного мозга; церебро- кардиальный синдром; кардиогемодинамика.

Keywords: focal ischemia of the brain; cerebrokardial syndrome; cardioghemmodynamics.


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