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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2018; 64(1): 3-10

CHANGES OF ONGOING ACTIVITY AND ELECTROPHYSIOLOGICAL CHARACTERISTICS OF THE RAT RETINAL GANGLION CELLS AT DIABETES MELLITUS

N.Ya. Martyniuk, V.Yu. Maslov, H.E. Purnyn, S.A. Fedulova, N.S. Veselovsky

    Bogomoletz Institute of Physiology NAS of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz64.01.003


Abstract

Changes of electrophysiological characteristics and ongoing activity parameters of the retinal ganglion cells (RGCs) on isolated rat retina were studied 3-4 weeks after streptozotocin (STZ) injection (80 mg/kg). It was shown that following electrophysiological characteristics significantly decreased: density of sodium current on 35 %, -0,84 ± 0,14 nA/pF in control and -0,55 ± 0,08 nA/pF at the STZ-induced diabetes mellitus (DM) and potassium current on 36 %, 1,36 ± 0,16 nA/ pF in control and 0,87 ± 0,14 nА/pF at DM, resting membrane potential on 10 %, -59 ± 1 mV in control and -53 ± 1 mV at DM. The mean frequency of ongoing postsynaptic currents reduced on 72 %, 2,5 ± 0.3 s-1 in control and 0,7 ± 0,1 s-1 at DM. The data suggest that pathological changes of the electrophysiological characteristics in RGCs appear at early stage of experimentally-induced DM.

Keywords: retinal ganglion cells; STZ-induced diabetes; voltage-dependent currents; postsynaptic currents.

Full text: (PDF, in Ukrainian)

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