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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2017; 63(6): 118-135


IMMUNOBIOLOGICAL PROPERTIES OF NEUROGENIC CELLS OF THE FETAL BRAIN. І. EXPRESSION OF MOLECULES WITH IMMUNE PROPERTIES

L.D. Liubich, M.I. Lisyany

    SI “Romodanov Neurosurgery Institute, National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz63.06.118

Abstract

The review presents an analysis of the current state of development of the problem of the brain neurogenic stem and progenitor cells (NSC / NPC) immunobiological properties. Section I summarizes data on NSC / NPC during the prenatal development. Discussion issues regarding the expression of histocompatibility antigens by NSC / NPC and mature nerve tissue cells in a comparative aspect, as well as the hierarchy of the antigen presenting potential of cells of the central nervous system are considered. Attention is drawn to the role of molecules of the main histocompatibility complex in the development of pre- and postnatal brain. Data on the expression of NSC / NPC immunoactive costimulatory molecules are given, which can determine their immunomodulating effect on cells of the immune system during contact interaction. The data on the expression and production of NSC / NPC immunoregulatory cytokines and growth factors are summarized; they are evidence of the mechanism of the regenerative action of these cells in neurotransplantation, the so-called. “bystander” effect, which justifies the concept of “functional or therapeutic plasticity”.

Keywords: Neurogenic stem cells, neurogenic progenitor cells, molecules of the main histocompatibility complex of I and II class, costimulatory molecules, cytokines, growth factors

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