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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2001; 47(6): 3-9

The influence of cyclic nucleotideson the membrane potential of intact endothelium of isolated rabbit aorta

V.V.Yarotskyy, V.F.Sagach, S.M.Marchenko

    A.A.Bogomoletz Institute of PhysiologyNational Academy of Science of Ukraine, Kiev



Abstract

The influence of intracellular cyclic nucleotides con- centration increase on the membrane potential of intact endothelium of isolated rabbit aorta has been investigated. Both applications of bucladesine, an adenosine 3?,5?-cyclic monophosphate (cAMP) mem- brane permeable analogue, and phoshophodiesterase blockers 3-isobutyl-1-methylxanthine (IBMX) and theophylline depolarized endothelial membrane. IBMX-induced depolarization was significantly smal- ler then theophylline-induced depolarization. It could be explained by the existence of IBMX-insen- sitive phosphodiesterases. Non-selective protein kinase blocker H-7 did not affect on the both IBMX-stimulated and non-stimulated membrane potential of aortic endo- thelium. It has been shown that the IBMX-induced depolarization and ATP-induced depolarization correlate with high correlation coefficient.

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