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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2017; 63(6): 99-105


CONTENT OF SIALIC ACID AND PEPSIN IN SALIVA AND GASTRIC JUICE OF PATIENTS WITH DISEASES OF STOMACH AND ESOPHAGUS

R.I. Zub1, S.V. Bychkova1, M.A. Bychkov2

  1. Ivan Franko National University of Lviv, Ukraine
  2. Danylo Galytsky National Medical University of Lviv, Ukraine
DOI: https://doi.org/10.15407/fz63.06.099

Abstract

It is an extremely important development and implementation into clinical practice of new affordable for widespread use of methods to diagnose acid-dependent diseases of the esophagus and stomach. One of these methods may be research of pepsin or sialic acid content in saliva and gastric juice of patients. We have analyzed samples of saliva and gastric juice in patients with gastroesophageal reflux disease (GERD) and chronic gastritis. The comparison was performed with samples taken in healthy volunteers (control). Measurement of pepsin content in the samples was carried out photometrically using biuret reagent, and sialic acids - using resorcinol. It was established that the content of sialic acids and pepsin in saliva of patients with GERD is higher than control. ROCanalysis showed that the sensitivities of the test are 61.1 % and 63.6 % and specificities are 85.7 % and 90.9 %, respectively. The ratios of pepsin’s content in saliva to it’s content in gastric juice are statistically significantly differented between the groups of patients with erosive and none erosive form GERD and between patients with gastritis. It was concluded, that measurement of sialic acids and pepsin in saliva might be a simple diagnostic method for determining GERD.

Keywords: Gastroesophageal reflux disease; gastritis; saliva; pepsin; sialic acid

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