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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2017; 63(6): 84-90


INFLUENCE OF CHRONIC POSTNATAL STRESS ON PRO- AND ANTIOXIDANT SYSTEM AND CHANGES OF AUTONOMIC BALANCE OF CARDIAC RHYTHM IN RATS

O.V.Denefil, І.R. Міts

    SHEI “I. Ya. Horbachevsky Ternopil State Medical University Ministry of Public Health of Ukraine”, Ukraine
DOI: https://doi.org/10.15407/fz63.06.084

Abstract

The effect of chronic postnatal stress on changes in autonomic regulation of cardiac rhythm, the state of the pro- and antioxidant system in 20 white, non-ostensibly sexually mature male rats and 24 females at the age of 3 months were studied. It was found that chronic postnatal stress in males rates causes a compensatory decrease in the regulatory influence of the sympathetic part of autonomic nervous system on the sinoarthrial node of the heart (the moda increased by 12.2%), they also changed automatism (heart rate decreased by 14.9%) and conductivity (increasing the duration of PQ by 30.24% and QTc by 7.78%), and in rats-females increased ventricular repolarization (T wave amplitude increase by 39.4 %). In the heart of the rats of both sexes exposed to stress, the processes of lipid peroxidation were intensified and the activity of the enzyme level of antioxidant increased, more significantly in males rats (increased activity of superoxide dismutase in 18 times, catalase in 2,9 times), as well as enzyme link of antioxidant system in blood (the content of ceruloplasmin increased in 1.5 times, peroxidase activity increased in 15.9 times). Consequently, chronic postnatal stress causes changes in autonomic regulation of cardiac rhythm, pro- and antioxidant systems which are more pronounced in males rats.

Keywords: Rats; stress; sex; heart; ECG, autonomic regulation; lipid peroxidation; antioxidant system

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