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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2017; 63(6): 66-71


THE INFLUENCE OF HYPOXIA AND MELATONIN ON THE BEHAVIORAL RESPONSE OF RATS WITH DIFFERENT LEVEL OF ENERGY METABOLISM

L.M. Plotnikova, V.Y. Berezovskyi, M.I. Levashov, O.G. Chaka, R.V. Yanko

    O.O. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz63.06.066

Abstract

We investigated the effect of intermittent normobaric hypoxia (INH) of sanogenic level and melatonin (5 mg/kg) on locomotor and emotional activity of young Wistar rats in the test «open field». The animals were divided into two groups: with low and high level of energy metabolism (LEM). Total locomotor activity in rats with high LEM control group was significantly lower by 17 % relatively low LEM rats. It was shown that joint ingestion of INH and melatonin increased horizontal motor activity by 22-38 %, decreased emotionality of rats in 2,5-2,7 times irrespective of their level of energy metabolism. In animals with low LEM, hypoxia, both separately and together with melatonin, increased the frequency (by 4,0 and 8,7 times, respectively) and the duration of the grooming (in 1,7 and 4,9 times, respectively) compared with the intact group. After 28 sessions of INH in them, the weight of the body significantly decreased by 10 % compared to the control. The combined action of INH and melatonin activated the orienting and research behavior of rats, reduced the level of anxiety, which may indicate an anti-stress effect of such influence. Key words:

Keywords: Intermittent normobaric hypoxia; melatonin; level of energy metabolism; behavioral response

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