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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2017; 63(6): 39-46


MECHANISM OF STRUCTURAL MYOCARDIAL REMODELING PREDICTORS DETERMINING IN PATIENTS WITH ATRIAL FIBRILLATION

A. Goryachyi, Yu.Karpenko, E. Levchenko, O. Gozhenko, A. Gozhenko

    Ukrainian Research Institute of Transport Medicine; Odessa Regional Clinical Hospital, Ukraine
DOI: https://doi.org/10.15407/fz63.06.039

Abstract

In this work, the content of matrix metalloproteinase-9 (MMP-9) in the blood serum was studied as an independent predictor of recurrence of atrial fibrillation after catheter radiofrequency ablation (CRA). The results of analyzes of patients with long-persistent form of atrial fibrillation (LPAF) lasting more than one year and resistant to drug therapy are analyzed. All patients before the procedure of catheter radiofrequency ablation measured the concentration of MMP-9 and evaluated its association with the recurrence of arrhythmias at the end of the postoperative period. For this, enzyme-linked dual enzyme immunoassay was used. 35 patients with LPAF were examined. The follow-up period was 16.2 + 5.7 months, in 12 (34.3%) patients there was a relapse of the arrhythmia after the ablation procedure. The basic content of MMP-9 was higher in patients with relapsed arrhythmia (261.3 + 35.3 and 202.46 + 27.6 ng/ml, respectively, P <0.05). Multivariate analysis showed that parameters such as MMP-9 content, a history of atrial fibrillation and a diameter of the left atrium were independent predictors of arrhythmia recurrence. Thus, MMP-9 is an independent predictor of arrhythmia recurrence after performing the procedure of catheter radiofrequency ablation in patients with atrial fibrillation.

Keywords: remodeling; matrix metalloproteinases; atrial fibrillation, catheter ablation

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