Українська English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2017; 63(6): 9-15

Population features of sex and stress hormones levels in young men blood serum

L.D. Popova, I.M. Vasylyeva, O.A. Nakonechnaya

    Kharkiv National Medical University, Ukraine
DOI: https://doi.org/10.15407/fz63.06.009


Abstract

Testosterone, estradiol, noradrenaline, adrenaline, cortisol levels in blood serum of Ukrainian and Indian young men and interrelations between those parameters, neuroticism and physical aggression were studied. Higher noradrenaline and estradiol contents were revealed in Indian men population as compared with Ukrainian one. Both in total group of participants and men of every population no interrelation between investigated parameters and neuroticism was found, but in Indian men the strong negative correlation between noradrenaline and physical aggression was observed. After division of all participants into 3 subgroups depending on neuroticism level, in persons with high neuroticism the significant positive correlation between neuroticism and cortisol and significant negative correlations between noradrenaline and neuroticism, between noradrenaline and physical aggression were observed. In individuals with middle neuroticism level the strong positive correlations between estradiol and neuroticism and between testosterone and physical aggression were found. Obtained results indicate the different contribution of cortisol and estradiol to formation of high and middle neuroticism levels. The increased content of noradrenaline in men of Indian population appears to provide the potent control of neuroticism and physical aggression expression. In all subgroups (Ukrainian and Indian men, persons with high and middle neuroticism) the strong positive correlation between testosterone to noradrenaline ratio and cortisol to noradrenaline ratio was found.

Keywords: Sex hormones; stress hormones; neuroticism; physical aggression; men

Full text: (PDF, in English)

References

  1. Neumann ID, Veenema AH, Beiderbeck DI. Aggression and anxiety: social context and neurobiological links. Front Behav Neurosci. 2010;4:1-12. CrossRef  
  2. Gauthier KJ, Furr RM, Mathias CW, Marsh-Richard DM, Dougherty DM. Differentiating impulsive and premeditated aggression: self and informant perspectives among adolescents with personality pathology. J Pers Disord. 2009;23(1):76-84. CrossRef PubMed PubMedCentral
    3.  
  3. Stanford MS, Houston RJ, Villemarette-Pittman NR, Greve KW. Premeditated aggression: Clinical assessment and cognitive psychophysiology. Personality and Individual Differences. 2003;34(5):773-81. CrossRef  
  4. Wingfield JC, Lynn S, Soma KK. Avoiding the 'costs' of testosterone: ecological bases of hormone-behavior interactions. Brain Behav. 2001;57:239-51. CrossRef PubMed
    5.  
  5. Chichinadze KN, Dominiadze TR, Matitaischvili T, Chichinadze NK, Lazaraschvili AG. Is the blood plasma testosterone level linked with aggressive behaviour of prisoner men? Bul Exp Biol Med. 2010;149(1):11-3. CrossRef  
  6. Roselli CE, Liu M, Hurn PD. Brain aromatization. Classical roles and new perspectives. Semin Reprod Med. 2009;27(3):207-17. CrossRef PubMed PubMedCentral
    7.  
  7. Blakemore SJ, Burnett S, Dahl RE. The role of puberty in the developing adolescent brain. Hum Brain Mapp. 2010;31(6):926-33. CrossRef PubMed PubMedCentral
    8.  
  8. van der Vegt BJ, Lieuwes N, Cremers TI, de Boer SF, Koolhaas JM. Cerebrospinal fluid monoamine and metabolite concentrations and aggression in rats. Horm Behav. 2003;44(3):199-208. CrossRef  
  9. Lee S, Jeong J, Kwak Y, Park SK. Depression research: where are we now? Mol Brain. 2010;3:8. CrossRef PubMed PubMedCentral
    10.  
  10. Thompson BL, Stanwood GD. Pleiotropic effects of neurotransmission during development: modulators of modularity. J Autism Dev Disord. 2009;39(2):260-68. CrossRef PubMed PubMedCentral
    11.  
  11. Foote SL, Morrison JH. Extrathalamic modulation of cortical function. Annu Rev Neurosci. 1987;10:67-95. CrossRef PubMed
    12.  
  12. de Kloet ER, Joels M, Holsboer F. Stress and the brain: from adaptation to disease. Nat Rev Neurosci. 2005;6:463-73. Hutchison JB. Gender-specific steroid metabolism in neural differentiation. Cell Mol Neurobiol. 1997;17(6):603-26. CrossRef  
  13. Swaab DF, Bao A.M, Lucassen PJ. The stress system in the human brain in depression and neurodegeneration. Ageing Res Rev. 2005;4(2):141-94. CrossRef PubMed
    14.  
  14. Bingham B, Gray M, Sun T, Viau V. Postnatal blockade of androgen receptors or aromatase impair the expression of stress hypothalamic-pituitary-adrenal axis habituation in adult male rats. Psychoneuroendocrinology. 2011;36(2):249-57. CrossRef PubMed
    15.  
  15. Reznikov AG, Nosenko ND, Tarasenko LV, Sinitsyn PV, Lymareva AA. Prenatal dexamethasone prevents early and long-lasting neuroendocrine and behavioral effects of maternal stress on male offspring. Fiziol Zh. 2008;54(5):28-39. PubMed
    16.  
  16. Berridge CW, Waterhouse BD. The locus coeruleusnoradrenergic system: modulation of behavioral state and state-dependent cognitive processes. Brain Res Brain Res Rev. 2003;42(1):33-84. CrossRef  
  17. Reznikov AG. Mechanisms of development of functional pathology of reproduction and adaptation in early ontogenesis. Zh AMN of Ukraine. 1998;4(2):216-33.
    18.  
  18. Prokopova I. Noradrenalin and behavior. Cesk. Fysiol. 2010;59(2):51-8. PubMed
    19.  
  19. Samuels ER, Zabadi ES. Functional neuroanatomy of the noradrenergic locus coeruleus: its roles in the regulation of arousal and autonomic function. Part I: Principles of functional organization. Curr. Neuropharmacol. 2008;6(3):235-53. CrossRef PubMed PubMedCentral
    20.  
  20. Lu Y, Simpson KL, Weaver KJ, Lin RC. Differential distribution patterns from medial prefrontal cortex and dorsal raphe to the locus coeruleus in rats. Anat Rec (Hoboken). 2012;295(7):1192-201. CrossRef PubMed PubMedCentral
    21.  
  21. van der Vegt BJ, Lieuwes N, Cremers TI, de Boer SF, Koolhaas JM. Cerebrospinal fluid monoamine and metabolite concentrations and aggression in rats. Horm Behav. 2003;44(3):199-208. CrossRef  
  22. Young EA, Abelson JL, Cameron OG. Interaction of brain noradrenergic system and the hypothalamic-pituitaryadrenal (HPA) axis in man. Psychoneuroendocrinology. 2005;30(8):807-14. CrossRef PubMed
    23.  
  23. Funk D, Stewart J. Role of catecholamines in the frontal cortex in the modulation of basal and stress-induced autonomic output in rats. Brain Res. 1996;741(1-2):220-9. CrossRef  
  24. Hess C, Reif A, Strobel A, Boreatti-Hummer A, Heine M, Lesch K P , Jacob CP. A functional dopamine-betahydroxylase gene promoter polymorphism is associated with impulsive personality styles, but not with affective disorders. J Neural Transm (Vienna). 2009;116(2):121-30. CrossRef PubMed
    25.  
  25. Logue SF, Gould TJ. The neural and genetic basis of executive function: attention, cognitive flexibility, and response inhibition. Pharmacol Biochem Behav. 2014;123:45-54. CrossRef PubMed PubMedCentral
    26.  
  26. Mehta PH, Josephs RA, "Testosterone and cortisol jointly regulate dominance: evidence for a dual-hormone hypothesis". Horm Behav. 2010;58(5):898-906. CrossRef PubMed
    27.  
  27. Stefansson J, Chatzittofis A, Nordstrom P et al. "CSF and plasma testosterone in attempted suicide". Psychoneuroendocrinology. 2016;74:1-6. CrossRef PubMed
    28.  
  28. Meyers B, Kritzer MF. In vitro binding assays using (3)H nisoxetine and (3)H WIN 35,428 reveal selective effects of gonadectomy and hormone replacement in adult male rats on norepinephrine but not dopamine transporter sites in the cerebral cortex. Neuroscience. 2009;159(1):271-82. CrossRef PubMed PubMedCentral
© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.