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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2017; 63(5): 80-93


CALCIFICATION OF HEART AND VESSELS IN CHRONIC KIDNEY DISEASE: PROBLEMS OF ETIOLOGY AND PATHOGENESIS

О.B. Susla1, А.I. Gozhenko2, J. Bergier3, І.R. Мysula1, М.I. Shved1, O.M. Lykhodid2

  1. I.Horbachevsky Ternopil State Medical University, Ukraine
  2. Ukrainian Scientific Research Institute of Transport Medicine, Odesa, Ukraine
  3. Pope John Paul II State Higher School in Biala Podlaska,Poland
DOI: https://doi.org/10.15407/fz63.05.080

Abstract

Literature data and our research results have been summarized, regarding the reasons and development mechanisms of cardiovascular system calcification in chronic kidney disease. The role of the disordered mineral metabolism, inflammation, uremic intoxication and endothelial damage with development of nitric oxide deficiency has been underlined in formation and progression of ectopic calcifications. Significant effect of hemodialysis treatment upon accelerated mechanisms of athero- and arteriosclerosis has been shown in patients with end-stage renal disease. There is a need of further studies on etiology and pathogenesis of cardiovascular calcifications in chronic renal dysfunction in order to optimize the early diagnosis, implementation of new effective preventive and treatment strategies, stratification of cardiovascular risk.

Keywords: Chronic kidney disease; cardiovascular system; calcification; risk factors; pathogenesis; endothelial damage/ dysfunction.

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