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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2017; 63(5): 62-69


N.M. Shpakova, E.A. Semionova, I.F. Kovalenko, N.A. Iershova, N.V. Orlova

    Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv, Ukraine


The effect of chlorpromazine on posthypertonic lysis of erythrocytes was studied with the assessment of the temperature dependence of morphological features of the cells. High antihemolitic activity of chlorpromazine under conditions of posthypertonic shock of erythrocytes was established at 0, but not at 37°C. When chlorpromazine (600 μmol/L) was used, its maximal antihemolytic activity amounted 77%. Erythrocytes survived posthypertoniс shock and chlorpromazine (180 and 600 μmol/L), were subjected to subsequent heating (6, 15, 24, 34 °C). In the presence of 600 μmol/L chlorpromazine, the cells changed their shape (from stomatocytes to spherostomatocytes) and hemolyzed. When 180 μmol/L chlorpromazine was used the red cells with the signs of stomatocytosis acquired the features inherent to echinocyte forms, while the number of cells was not decreased.

Keywords: Human erythrocytes; posthypertonic shock; chlorpromazine; temperature; stomatocyte; spherostomatocyte; echinocyte.


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