On white nonlinear male rats (200-250 g), we investigated the content of moisture, collagen, melted gelatin and the temperature of welding in the skin of animals with full-thickness wounds and chemical burn, without treatment and under the treatment by a new pharmacological melanin-containing composition. The physical and chemical indices of the skin were examined on white nonlinear male rats (the full-thickness wound was simulated with a stencil and surgical tweezers, chemical burn, by subcutaneous injection with 0.1 ml (10%) of CaCl2. Moisture content was reduced by 36% in a wound, during chemical burn by 48%. In addition, we observed an increase in the collagen content by 40 and 52%, respectively. When correcting the pathology by melanin, the normalization of the investigated parameters was detected. As tissue scarring does not occur, the gelatin yield decreases in the cut wounds by 40 %, and the skin welding temperature decreases. Тhe melanin composition that we created can be recommended as a dermatotropic agent for the treatment of skin wounds of various origins.