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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2017; 63(5): 28-33


O.V. Taburets, V.V. Vereschaka, T.V. Beregova, L.I. Ostapchenko

    Education and Research center «Institute of Biology» Taras Shevchenko National University of Kyiv


On white nonlinear male rats (200-250 g), we investigated the content of moisture, collagen, melted gelatin and the temperature of welding in the skin of animals with full-thickness wounds and chemical burn, without treatment and under the treatment by a new pharmacological melanin-containing composition. The physical and chemical indices of the skin were examined on white nonlinear male rats (the full-thickness wound was simulated with a stencil and surgical tweezers, chemical burn, by subcutaneous injection with 0.1 ml (10%) of CaCl2. Moisture content was reduced by 36% in a wound, during chemical burn by 48%. In addition, we observed an increase in the collagen content by 40 and 52%, respectively. When correcting the pathology by melanin, the normalization of the investigated parameters was detected. As tissue scarring does not occur, the gelatin yield decreases in the cut wounds by 40 %, and the skin welding temperature decreases. Тhe melanin composition that we created can be recommended as a dermatotropic agent for the treatment of skin wounds of various origins.

Keywords: full-thickness wound; chemical burn; collagen; melanin.


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