THE RATS LIVER EXTERNAL SECRETORY FUNCTION IN BLOCKADE OF ANDROGEN RECEPTORS WITH FLUTAMIDE
I.S. Chernuha1, Ye.M. Reshetnik1, S.P. Veselsky1, A.G. Reznikov2, M.Yu. Makarchuk1
- Kyiv National Taras Shevchenko University, Kyiv, Ukraine
- V.P. Komisarenko Institute of Endocrinology and Metabolism
Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz63.05.021
Abstract
The effects of flutamide (25 mg / kg, intragastric, daily, for
three days) on bile formation in male rats were investigated.
The volume rate of bile secretion decreased in male rats under the influence of flutamide. It was found a significant reduction
of the glycoconjugated bile acids concentration in the bile of
the male rats under flutamide action. So, glycochenodeoxycholate
and glycodeoxycholate concentration in the bile are
significantly lower (16,3 – 34,5 %) in male rats under the
flutamide action than in bile samples of the control group
animals. But it was found that flutamide does not change the
ratio of the total conjugated bile acids to unconjugated bile
acids. Flutamide inhibits hydroxylation of bile acids in the male
rats. The coefficient of the bile acids hydroxylate is decreased
under the influence of flutamide compared to control by 10,1%.
Thus, flutamide decreases bile flow, conjugation of the bile
acids with glycine and glycoconjugates transport into the bile.
Keywords:
liver; bile; bile acid; androgen receptors; flutamide
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