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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 1999; 45(6): 92-104

Free radical processesunder different oxygen supply conditions. the review

T. V. Serebrovskaya, O. S. Safronova, S. K. Gordiy

    A.A. Bogomoletz Institute of Physiology,National Academy of Sciences of Ukraine, Kiev;I. Franko University, Ministry of Education of Ukraine, L’viv



Abstract

Free radical processes (FRP) in mammalian organism are oxygen-depended. The review is devoted to the analysis of pro- and antioxidant processes in mammalian tissues under different oxygen supply conditions. There are described: sources of free radicals; hyperproduction of FRP under hyperoxia and hyperbaria; the role of free radicals in the adaptation to chronic hypoxia (high altitudes, barochamber, chronic heart and lung diseases); production of active oxygen species during the reoxygenation of preliminarily hypoxic tissues; FRP under intermittent hypoxic training; role of FRP in the chemoreception of oxygen. The special attention is paid to three main factors underlined the FR production in hypoxic conditions: the speed of hypoxia increase, the degree of hypoxia and the time of hypoxic exposure.

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