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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2017; 63(5): 13-20


HYPERSEXUAL BEHAVIOR AND HYPERANDROGENISM IN F1 MALE RATS CAUSED BY DIBUTYLPHTALATE TREATMENT OF PREGNANT FEMALES

A.G. Reznikov, O.V. Sachynska , A.A. Limareva, O.A. Falyush, I.G. Perchik

    State Institution “V.P. Komissarenko Institute of Endocrinology and Metabolism of National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz63.05.013

Abstract

The effect of di-n-butyl phtalate (DBP) prescribed to pregnant Wistar rats on the androgen function and male and female sexual behaviour of first generation male progeny was investigated. DBP was administered intragastrically through the gavage at a daily dose of 100 mg/kg during the 15 to 21 day of pregnancy. Male sexual behaviour was evaluated at the age of 6 and 10 months on proceptive responses in the presence of a receptive female, the duration of latent and refractory periods and the number of mountings, intromissions and ejaculations. The lordotic reactions were studied in castrated and activated with oestradiol and progesterone males in the presence of normal males. The findings indicate acceleration of puberty, a significant increase in males’ and females’ sexual behavior with significantly elevated testosterone levels of in blood plasma. Possible mechanisms of the revealed functional changes of the reproductive system are discussed.

Keywords: dibutyl phthalate; prenatal effect; sexual behavior; testosterone; male rats.

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