HYPERSEXUAL BEHAVIOR AND HYPERANDROGENISM IN F1 MALE RATS CAUSED BY DIBUTYLPHTALATE TREATMENT OF PREGNANT FEMALES
A.G. Reznikov, O.V. Sachynska , A.A. Limareva, O.A. Falyush, I.G. Perchik
State Institution “V.P. Komissarenko Institute of Endocrinology and Metabolism of National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz63.05.013
Abstract
The effect of di-n-butyl phtalate (DBP) prescribed to pregnant
Wistar rats on the androgen function and male and female
sexual behaviour of first generation male progeny was investigated.
DBP was administered intragastrically through the
gavage at a daily dose of 100 mg/kg during the 15 to 21 day
of pregnancy. Male sexual behaviour was evaluated at the age
of 6 and 10 months on proceptive responses in the presence of
a receptive female, the duration of latent and refractory periods
and the number of mountings, intromissions and ejaculations.
The lordotic reactions were studied in castrated and activated
with oestradiol and progesterone males in the presence of
normal males. The findings indicate acceleration of puberty, a
significant increase in males’ and females’ sexual behavior with
significantly elevated testosterone levels of in blood plasma.
Possible mechanisms of the revealed functional changes of
the reproductive system are discussed.
Keywords:
dibutyl phthalate; prenatal effect; sexual behavior; testosterone; male rats.
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