EFFECASY OF BISPHOSPHONIC ACIDS IN FEMALE RATS WITH EXPERIMENTAL OSTEOPOROSIS
V.V. Povoroznyuk1, V. I. Pekhnyo2, N.V. Grygorieva1, O.M. Kozachkova2, N.V. Tsaryk2
- State Institution «Institute of Gerontology named after
D. F. Chebotarev of NAMS Ukraine», Ukrainian ScientificMedical
Center of Osteoporosis, Kyiv, Ukraine
- Vernadsky Institute of general and inorganic chemistry of
the Ukrainian National Academy of Sciences, Kiev, Ukraine
We evaluated the efficiency of different types of bisphosphonic
acids, еthylidenebisphosphonic (EBP), aminoethylidenebisphosphonic
(PhHMBP) and 1-phenyl-1-fluoromethylenebisphosphonic
(PhFMBP) acids compared to zoledronic acid in combination of calcium and vitamin D supplementation
in female rats with experimental osteoporosis. Our results
established the absence of significant changes in bone mineral
density indexes in female rats after bilateral ovariectomy,
which received EBF, AEBF and FenHMBF in combination
with calcium and vitamin D supplements. We also showed the
significant dynamics of bone mineral density indices of total
body (from 0,100±0,007 tо 0,105±0,008 g/sm2 after 3 months)
in the rats which receive FenFMBF with calcium and vitamin
D administration. Our study requires further researches of the
effectiveness of FenFMBF in the prevention and treatment of
ethylidenebisphosphonic acid; aminoethylidenebisphosphonic acid; 1-phenyl-1-hydroxymethylenebisphosphonic acid; 1-phenyl-1-fluoromethylene-bisphosphonic acid; zoledronic acid; female rats; bone mineral density; experimental osteoporosis.
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