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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2017; 63(4): 80-86


EFFECASY OF BISPHOSPHONIC ACIDS IN FEMALE RATS WITH EXPERIMENTAL OSTEOPOROSIS

V.V. Povoroznyuk1, V. I. Pekhnyo2, N.V. Grygorieva1, O.M. Kozachkova2, N.V. Tsaryk2

  1. State Institution «Institute of Gerontology named after D. F. Chebotarev of NAMS Ukraine», Ukrainian ScientificMedical Center of Osteoporosis, Kyiv, Ukraine
  2. Vernadsky Institute of general and inorganic chemistry of the Ukrainian National Academy of Sciences, Kiev, Ukraine
DOI: https://doi.org/10.15407/fz63.04.080

Abstract

We evaluated the efficiency of different types of bisphosphonic acids, еthylidenebisphosphonic (EBP), aminoethylidenebisphosphonic (AEBP), 1-phenyl-1-hydroxymethylenebisphosphonic (PhHMBP) and 1-phenyl-1-fluoromethylenebisphosphonic (PhFMBP) acids compared to zoledronic acid in combination of calcium and vitamin D supplementation in female rats with experimental osteoporosis. Our results established the absence of significant changes in bone mineral density indexes in female rats after bilateral ovariectomy, which received EBF, AEBF and FenHMBF in combination with calcium and vitamin D supplements. We also showed the significant dynamics of bone mineral density indices of total body (from 0,100±0,007 tо 0,105±0,008 g/sm2 after 3 months) in the rats which receive FenFMBF with calcium and vitamin D administration. Our study requires further researches of the effectiveness of FenFMBF in the prevention and treatment of systemic osteoporosis.

Keywords: ethylidenebisphosphonic acid; aminoethylidenebisphosphonic acid; 1-phenyl-1-hydroxymethylenebisphosphonic acid; 1-phenyl-1-fluoromethylene-bisphosphonic acid; zoledronic acid; female rats; bone mineral density; experimental osteoporosis.

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