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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2017; 63(4): 56-63


O.A. Khodakovskyi, I.L. Chereshniuk, O.I. Alchuk, L.I. Marynych, R.A. Kravets, O.V. Khodakivska

    National Pirogov Memorial Medical University, Vinnytsya, Ukraine


Using model of hemorrhagic stroke in rats (heparinized autologous blood was injected into the subarachnoid space at a dose of 0.1 ml/100 g), we discovered that 21 days course of intravenous therapy with 1% solution of 1-adamantiloxy- 3-morpholino-2-propanolhydrochloride (ademol) at a dose of 2 mg/kg was more effective to reduce neurological deficit (from severe to moderate by stroke-index, p<0.05) and improve mnemotropic activity in the test of passive avoidance compared to nimodipine at a dose of 30 mg/kg. These findings proved neuroprotective properties of ademol. Therapy with ademol as well as with reference drug in the acute phase of subarachnoid hemorrhage (4th day) resulted in a decrease in the number of cells with fragmented DNA in the visual cortex in rats. The results of our study indicated anti-apoptotic action of ademol on the cortical neurons after hemorrhagic stroke. Taking into account pronounced mnemotropic and anti-apoptotic effects of ademol, it has been classified as a primary neuroprotective drug and can be used as pathogenetic therapeutic agent to prevent early cell death after stroke in human.

Keywords: ademol; nimodipine; subarachnoid hemorrhage; apoptosis; neurological deficit; memory; neuroprotection; rats.


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