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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2017; 63(4): 56-63

EFFECTS OF NDMA RECEPTOR ADEMOL ON FUNCTIONS AND APOPTOSIS IN VISUAL CORTEX AFTER SUBARACHNOID HEMORRHAGE IN RATS

O.A. Khodakovskyi, I.L. Chereshniuk, O.I. Alchuk, L.I. Marynych, R.A. Kravets, O.V. Khodakivska

    National Pirogov Memorial Medical University, Vinnytsya, Ukraine
DOI: https://doi.org/10.15407/fz63.04.056


Abstract

Using model of hemorrhagic stroke in rats (heparinized autologous blood was injected into the subarachnoid space at a dose of 0.1 ml/100 g), we discovered that 21 days course of intravenous therapy with 1% solution of 1-adamantiloxy- 3-morpholino-2-propanolhydrochloride (ademol) at a dose of 2 mg/kg was more effective to reduce neurological deficit (from severe to moderate by stroke-index, p<0.05) and improve mnemotropic activity in the test of passive avoidance compared to nimodipine at a dose of 30 mg/kg. These findings proved neuroprotective properties of ademol. Therapy with ademol as well as with reference drug in the acute phase of subarachnoid hemorrhage (4th day) resulted in a decrease in the number of cells with fragmented DNA in the visual cortex in rats. The results of our study indicated anti-apoptotic action of ademol on the cortical neurons after hemorrhagic stroke. Taking into account pronounced mnemotropic and anti-apoptotic effects of ademol, it has been classified as a primary neuroprotective drug and can be used as pathogenetic therapeutic agent to prevent early cell death after stroke in human.

Keywords: ademol; nimodipine; subarachnoid hemorrhage; apoptosis; neurological deficit; memory; neuroprotection; rats.

Full text: (PDF, in Ukrainian)

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