MAGNETIC FIELD EFFECT ON BLOOD OXYGEN TRANSPORT FUNCTION UNDER IMPACT OF A DONOR OF HYDROGEN SULPHIDE
V.V. Zinchuk, V.O. Lepeev
Grodno State Medical University, Belarus
Gaseous transmitters (hydrogen
sulphide, NO) belong
to the representatives of gaseous
which are important in the
translation of physiological
signals. But hydrogen sulphide
participation in magnetic
field (MF) effects on
oxygen transport function
modification are still poorly
understood. Aim of the work
was to evaluate MF effect
on blood oxygen transport
function under impact of a
donor of hydrogen sulphide.
Experiments were conducted
on white male rats. MF application
on rat tail artery and
intraperitoneal injection of
different substances, аffecting
the formation of hydrogen
sulphide: sodium hydrosulfide
(NaHS); L-arginine; a nonselective
nitric oxide synthase
inhibitor - NG-nitro-L-arginine
methyl ester (L-NAME);
an irreversible inhibitor of the enzyme cystathionine γ-lyase DL-Propargylglycine (PAG)
were performed over 10 days. Indices of blood oxygen transport
function, the level of hydrogen sulphide and the level of
- in blood plasma were estimated. It was shown that
MF irradiation of rats tail artery and the injection of NaHS
or amino acid L-arginine for 10 days leaded to a decrease
of the hemoglobin oxygen affinity and was accompanied
by an increased gaseous transmitters concentration (NO and
hydrogen sulfide) in the blood. During administration of LNAME
and PAG MF effect on hemoglobin oxygen affinity
did not occur. MF modifies blood oxygen transport function
through the action of gaseous transmitter hydrogen sulphide
with the participation of NO.
magnetic field; blood; gaseous transmitters; oxygen; hydrogen sulphide.
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