Українська Русский English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2017; 63(4): 30-36


MAGNETIC FIELD EFFECT ON BLOOD OXYGEN TRANSPORT FUNCTION UNDER IMPACT OF A DONOR OF HYDROGEN SULPHIDE

V.V. Zinchuk, V.O. Lepeev

    Grodno State Medical University, Belarus
DOI: https://doi.org/10.15407/fz63.04.030

Abstract

Gaseous transmitters (hydrogen sulphide, NO) belong to the representatives of gaseous signaling compounds, which are important in the translation of physiological signals. But hydrogen sulphide participation in magnetic field (MF) effects on oxygen transport function modification are still poorly understood. Aim of the work was to evaluate MF effect on blood oxygen transport function under impact of a donor of hydrogen sulphide. Experiments were conducted on white male rats. MF application on rat tail artery and intraperitoneal injection of different substances, аffecting the formation of hydrogen sulphide: sodium hydrosulfide (NaHS); L-arginine; a nonselective nitric oxide synthase inhibitor - NG-nitro-L-arginine methyl ester (L-NAME); an irreversible inhibitor of the enzyme cystathionine γ-lyase DL-Propargylglycine (PAG) were performed over 10 days. Indices of blood oxygen transport function, the level of hydrogen sulphide and the level of NO2 - /NO3 - in blood plasma were estimated. It was shown that MF irradiation of rats tail artery and the injection of NaHS or amino acid L-arginine for 10 days leaded to a decrease of the hemoglobin oxygen affinity and was accompanied by an increased gaseous transmitters concentration (NO and hydrogen sulfide) in the blood. During administration of LNAME and PAG MF effect on hemoglobin oxygen affinity did not occur. MF modifies blood oxygen transport function through the action of gaseous transmitter hydrogen sulphide with the participation of NO.

Keywords: magnetic field; blood; gaseous transmitters; oxygen; hydrogen sulphide.

References

  1. Varaksin AA, Pushhina EV. Role of hydrogen sulphide in regulatory functions. Pacific Med J. 2012;48(2):27-36.
  2.  
  3. Zinchuk VV, Glutkina NV. Oxygen-binding capacities of hemoglobin and nitric oxide. Rus J Physiol. I.M. Sechenova. 2013;99(5):537-54.
  4.  
  5. Zinchuk VV, Lepeev VO, Guliaj IE. Participation of gaseous transmitters in blood oxygen transport function modification under the influence of magnetic field. Rus J Physiol I.M. Sechenova. 2016;102(10):1176-84.
  6.  
  7. Sagach VF, Shimanskaya TV, Goshowska YV. Influence of stimulation and blockade of endogenous synthesis of hydrogen sulfide on cardiac function in ischemiareperfusion. Fiziol Zh. 2013;59(4):8-15 [Ukrainian].
  8.  
  9. Spas VV, Yakubtsevich RE. Respiratory distress syndrome of adults. Minsk: Ipati, 2007. PubMed
  10.  
  11. Ulashhik VS. Elements of molecular physiotherapy. Minsk: Belaruskaya Navuka, 2014.
  12.  
  13. Chertok VM, Zenkina VG. Regulation of Ovarian Function: Part of the gas transmitters NO, CO and H2S. Successes Physiol Sci. 2015;(4):74-89.
  14.  
  15. Altaany Z, Yang G., Wang R. Crosstalk between hydrogen sulfide and nitric oxide in endothelial cells. J Cell Mol Med. 2013;17(7):879-888. CrossRef PubMed PubMedCentral
  16.  
  17. Geng B, Chang L, Pan C, Qi Y, Zhao J, Pang Y, Du J, Tang C. Endogenous hydrogen sulfide regulation of myocardial injury induced by isoproterenol. Biochem Biophys Res Commun. 2004;318(3):756-63. CrossRef PubMed
  18.  
  19. Ishigami M, Hiraki K, Umemura K, Ogasawara Y, Ishii K, Kimura H. A source of hydrogen sulfide and a mechanism of its release in the brain. Antioxid Redox Signal. 2009;11(2):205-14. CrossRef PubMed
  20.  
  21. Kimura H. Metabolic turnover of hydrogen sulfide. Frontiers in Physiology. [cited 2012 Apr 18]; vailable from: Kolluru GK, Prasai PK, Kaskas AM, Letchuman V, Pattillo CB. Oxygen tension, H2S, and NO bioavailability: is there an interaction? J Appl Physiol. 2016;120:263-70.
  22.  
  23. Kolluru GK, Prasai PK, Kaskas AM, Letchuman V, Pattillo CB. Oxygen tension, H2S, and NO bioavailability: is there an interaction? J Appl Physiol. 2016;120:263-70 CrossRef PubMed
  24. Marx SO, Reiken S, Hisamatsu Y, Jayaraman T, Burkhoff D, Rosemblit N, Marks AR. Protein kinase A phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell. 2000;101(4):365-76. CrossRef  
  25. Norris EJ, Culberson CR, Narasimhan S, Clemens MG. The Liver as a Central Regulator of Hydrogen Sulfide. Shock. 2011;36(3):242-50. CrossRef PubMed PubMedCentral
  26.  
  27. Pan T-T, Feng Z-N, Lee SW, Moore P K, Bian J-S. Endogenous hydrogen sulfide contributes to the cardioprotection by metabolic inhibition preconditioning in the rat ventricular myocytes. J Mol Cell Cardiol. 2006;40(1):119-30. CrossRef PubMed
  28.  
  29. Severinghaus JW. Blood gas calculator. J Appl Physiol. 1966;21(5):1108-16. CrossRef PubMed
  30.  
  31. Szabo C. Hydrogen sulfide, an enhancer of vascular nitric oxide signaling: mechanisms and implications. Am J Physiol - Cell Physiol. 2017;312(1):3-15. CrossRef PubMed PubMedCentral
  32.  
  33. Yong QC, Lee SW, Foo CS, Neo KL, Chen X, Bian J-S. Endogenous hydrogen sulphide mediates the cardioprotection induced by ischemic postconditioning. Am J Physiol - Heart and Circul Physiol. 2008;295(3):1330-40. CrossRef PubMed
  34.  
  35. Zhao W, Ndisang J F, Wang R. Modulation of endogenous production of H2S in rat tissues. Canad J Physiol Pharmacol. 2003;81(9):848-53. CrossRef PubMed
  36.  
  37. Zhu YZ, Wang Z, Ho P, Loke YY, Zhu YC, Huang XW, Huang SH, Tan CS, Whiteman M, Lu J, Moore PK. Hydrogen sulfide and its possible roles in myocardial ischemia in experimental rats. J Appl Physiol. 2007;102(1):261-268. CrossRef PubMed

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2020.