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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2017; 63(4): 30-36


V.V. Zinchuk, V.O. Lepeev

    Grodno State Medical University, Belarus


Gaseous transmitters (hydrogen sulphide, NO) belong to the representatives of gaseous signaling compounds, which are important in the translation of physiological signals. But hydrogen sulphide participation in magnetic field (MF) effects on oxygen transport function modification are still poorly understood. Aim of the work was to evaluate MF effect on blood oxygen transport function under impact of a donor of hydrogen sulphide. Experiments were conducted on white male rats. MF application on rat tail artery and intraperitoneal injection of different substances, аffecting the formation of hydrogen sulphide: sodium hydrosulfide (NaHS); L-arginine; a nonselective nitric oxide synthase inhibitor - NG-nitro-L-arginine methyl ester (L-NAME); an irreversible inhibitor of the enzyme cystathionine γ-lyase DL-Propargylglycine (PAG) were performed over 10 days. Indices of blood oxygen transport function, the level of hydrogen sulphide and the level of NO2 - /NO3 - in blood plasma were estimated. It was shown that MF irradiation of rats tail artery and the injection of NaHS or amino acid L-arginine for 10 days leaded to a decrease of the hemoglobin oxygen affinity and was accompanied by an increased gaseous transmitters concentration (NO and hydrogen sulfide) in the blood. During administration of LNAME and PAG MF effect on hemoglobin oxygen affinity did not occur. MF modifies blood oxygen transport function through the action of gaseous transmitter hydrogen sulphide with the participation of NO.

Keywords: magnetic field; blood; gaseous transmitters; oxygen; hydrogen sulphide.


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