MAGNETIC FIELD EFFECT ON BLOOD OXYGEN TRANSPORT FUNCTION UNDER IMPACT OF A DONOR OF HYDROGEN SULPHIDE
V.V. Zinchuk, V.O. Lepeev
Grodno State Medical University, Belarus
DOI: https://doi.org/10.15407/fz63.04.030
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Abstract
Gaseous transmitters (hydrogen
sulphide, NO) belong
to the representatives of gaseous
signaling compounds,
which are important in the
translation of physiological
signals. But hydrogen sulphide
participation in magnetic
field (MF) effects on
oxygen transport function
modification are still poorly
understood. Aim of the work
was to evaluate MF effect
on blood oxygen transport
function under impact of a
donor of hydrogen sulphide.
Experiments were conducted
on white male rats. MF application
on rat tail artery and
intraperitoneal injection of
different substances, аffecting
the formation of hydrogen
sulphide: sodium hydrosulfide
(NaHS); L-arginine; a nonselective
nitric oxide synthase
inhibitor - NG-nitro-L-arginine
methyl ester (L-NAME);
an irreversible inhibitor of the enzyme cystathionine γ-lyase DL-Propargylglycine (PAG)
were performed over 10 days. Indices of blood oxygen transport
function, the level of hydrogen sulphide and the level of
NO2
-
/NO3
- in blood plasma were estimated. It was shown that
MF irradiation of rats tail artery and the injection of NaHS
or amino acid L-arginine for 10 days leaded to a decrease
of the hemoglobin oxygen affinity and was accompanied
by an increased gaseous transmitters concentration (NO and
hydrogen sulfide) in the blood. During administration of LNAME
and PAG MF effect on hemoglobin oxygen affinity
did not occur. MF modifies blood oxygen transport function
through the action of gaseous transmitter hydrogen sulphide
with the participation of NO.
Keywords:
magnetic field; blood; gaseous transmitters; oxygen; hydrogen sulphide.
References
- Varaksin AA, Pushhina EV. Role of hydrogen sulphide in regulatory functions. Pacific Med J. 2012;48(2):27-36.
- Zinchuk VV, Glutkina NV. Oxygen-binding capacities of hemoglobin and nitric oxide. Rus J Physiol. I.M. Sechenova. 2013;99(5):537-54.
- Zinchuk VV, Lepeev VO, Guliaj IE. Participation of gaseous transmitters in blood oxygen transport function modification under the influence of magnetic field. Rus J Physiol I.M. Sechenova. 2016;102(10):1176-84.
- Sagach VF, Shimanskaya TV, Goshowska YV. Influence of stimulation and blockade of endogenous synthesis of hydrogen sulfide on cardiac function in ischemiareperfusion. Fiziol Zh. 2013;59(4):8-15 [Ukrainian].
- Spas VV, Yakubtsevich RE. Respiratory distress syndrome of adults. Minsk: Ipati, 2007.
PubMed
- Ulashhik VS. Elements of molecular physiotherapy. Minsk: Belaruskaya Navuka, 2014.
- Chertok VM, Zenkina VG. Regulation of Ovarian Function: Part of the gas transmitters NO, CO and H2S. Successes Physiol Sci. 2015;(4):74-89.
- Altaany Z, Yang G., Wang R. Crosstalk between hydrogen sulfide and nitric oxide in endothelial cells. J Cell Mol Med. 2013;17(7):879-888.
CrossRef
PubMed PubMedCentral
- Geng B, Chang L, Pan C, Qi Y, Zhao J, Pang Y, Du J, Tang C. Endogenous hydrogen sulfide regulation of myocardial injury induced by isoproterenol. Biochem Biophys Res Commun. 2004;318(3):756-63.
CrossRef
PubMed
- Ishigami M, Hiraki K, Umemura K, Ogasawara Y, Ishii K, Kimura H. A source of hydrogen sulfide and a mechanism of its release in the brain. Antioxid Redox Signal. 2009;11(2):205-14.
CrossRef
PubMed
- Kimura H. Metabolic turnover of hydrogen sulfide. Frontiers in Physiology. [cited 2012 Apr 18]; vailable from: Kolluru GK, Prasai PK, Kaskas AM, Letchuman V, Pattillo CB. Oxygen tension, H2S, and NO bioavailability: is there an interaction? J Appl Physiol. 2016;120:263-70.
- Kolluru GK, Prasai PK, Kaskas AM, Letchuman V, Pattillo CB. Oxygen tension, H2S, and NO bioavailability: is there an interaction? J Appl Physiol. 2016;120:263-70
CrossRef
PubMed
- Marx SO, Reiken S, Hisamatsu Y, Jayaraman T, Burkhoff D, Rosemblit N, Marks AR. Protein kinase A phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell. 2000;101(4):365-76.
CrossRef
- Norris EJ, Culberson CR, Narasimhan S, Clemens MG. The Liver as a Central Regulator of Hydrogen Sulfide. Shock. 2011;36(3):242-50.
CrossRef
PubMed PubMedCentral
- Pan T-T, Feng Z-N, Lee SW, Moore P K, Bian J-S. Endogenous hydrogen sulfide contributes to the cardioprotection by metabolic inhibition preconditioning in the rat ventricular myocytes. J Mol Cell Cardiol. 2006;40(1):119-30.
CrossRef
PubMed
- Severinghaus JW. Blood gas calculator. J Appl Physiol. 1966;21(5):1108-16.
CrossRef
PubMed
- Szabo C. Hydrogen sulfide, an enhancer of vascular nitric oxide signaling: mechanisms and implications. Am J Physiol - Cell Physiol. 2017;312(1):3-15.
CrossRef
PubMed PubMedCentral
- Yong QC, Lee SW, Foo CS, Neo KL, Chen X, Bian J-S. Endogenous hydrogen sulphide mediates the cardioprotection induced by ischemic postconditioning. Am J Physiol - Heart and Circul Physiol. 2008;295(3):1330-40.
CrossRef
PubMed
- Zhao W, Ndisang J F, Wang R. Modulation of endogenous production of H2S in rat tissues. Canad J Physiol Pharmacol. 2003;81(9):848-53.
CrossRef
PubMed
- Zhu YZ, Wang Z, Ho P, Loke YY, Zhu YC, Huang XW, Huang SH, Tan CS, Whiteman M, Lu J, Moore PK. Hydrogen sulfide and its possible roles in myocardial ischemia in experimental rats. J Appl Physiol. 2007;102(1):261-268.
CrossRef
PubMed
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