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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2017; 63(4): 17-23


NGF - INDUCED CHANGES IN ADRENERGIC MODULATION OF CALCIUM CHANNELS OF TRIGEMINAL GANGLION NEURONS

M.V. Telka, O.V. Rikhalsky, N.S. Veselovsky

    O.O. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz63.04.017

Abstract

We investigated the influence of nerve growth factors (NGF) on adrenergetic modulation voltage dependent calcium currents (VDCC) in trigeminal ganglion neurons. Noradrenalin had no effect on low VDCC but inhibited the high VDCC. Application of noradrenalin (100 µM) resulted in decrease amplitude of high VDCC by (30±5)% and (13±8)% under with or without addition of NGF in the culture medium respectively. When NGF was administered in the TG cell cultures, noradrenalin depressed fast component of high VDCC in majority of neurons (11 of 13).Only in three units of 15 were observed changes in the kinetics of high VDCC under condition without NGF. The changes in the kinetics of high VDCC were accompanied by shifting steady-state inactivation curves to more negative values. These data showed that high voltage dependent calcium channels are involved in adrenergic modulation in TG neurons. In the presence of NGF this effect is enhanced. Our researches were suggest the increase levels of NGF contributed to effect on adrenergic modulation.

Keywords: trigeminal ganglion neurons; voltage dependent calcium channels; noradrenalin; nerve growth factor.

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