INTERACTIONS BETWEEN IMMUNE SYSTEM PARAMETERS AND THYROID STATUS IN PEOPLE FROM RADIOACTIVE CONTAMINATED AREAS BY THE CONDITIONS OF EMOTIONAL STRESS
V.L. Sokolenko, S.V. Sokolenko
Bohdan Khmelnytsky National University of Cherkasy
We have been studying specifics of interactions between immune
system and thyroid status among inhabitants of radioactive
contaminated areas who suffered further emotional stress.
The research involved 70 people from relatively environmentally
friendly areas (control group) and 100 people from the
radiation zone IV. All examined are National University of
Cherkasy students aged 18 to 24 years. The main factor that
led to the formation of emotional stress was winter examination
session. It was determined that 48% of examined taken from
the areas of enhanced radiation monitoring showed the signs
of hyperthyroidism. In this case, people with high content of
triiodothyronine (Т3) in peripheral blood showed some definite
tension in their thyroid system, which was characterized
by increasing concentration of thyrotrophic hormone (TSH,
3.67±0.25 μIU/mL compared with control group – 2.31±0.21
μIU/mL). Under conditions of additional emotional stress
in patients with symptoms of hyperthyroidism a significant
reduction of triiodothyronine level was observed (from
2.59±0.07 to 1.71±0.07 nmol/l) along with the absence of
changes in thyroxine level and tendency to reduction of TSH. This effect was also accompanied by a decrease in correlation
index between T3 level and some definite indicators of cellular
immunity. The revealed features may indicate a depletion of
adaptive capacity of thyroid system caused by the prolonged
effects of low doses of ionizing radiation.
immune system; thyroid status; contamination; stress; cortisol; deconditioning
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