Українська Русский English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2017; 63(3): 32-39


INTERACTIONS BETWEEN IMMUNE SYSTEM PARAMETERS AND THYROID STATUS IN PEOPLE FROM RADIOACTIVE CONTAMINATED AREAS BY THE CONDITIONS OF EMOTIONAL STRESS

V.L. Sokolenko, S.V. Sokolenko

    Bohdan Khmelnytsky National University of Cherkasy
DOI: https://doi.org/10.15407/fz63.03.032

Abstract

We have been studying specifics of interactions between immune system and thyroid status among inhabitants of radioactive contaminated areas who suffered further emotional stress. The research involved 70 people from relatively environmentally friendly areas (control group) and 100 people from the radiation zone IV. All examined are National University of Cherkasy students aged 18 to 24 years. The main factor that led to the formation of emotional stress was winter examination session. It was determined that 48% of examined taken from the areas of enhanced radiation monitoring showed the signs of hyperthyroidism. In this case, people with high content of triiodothyronine (Т3) in peripheral blood showed some definite tension in their thyroid system, which was characterized by increasing concentration of thyrotrophic hormone (TSH, 3.67±0.25 μIU/mL compared with control group – 2.31±0.21 μIU/mL). Under conditions of additional emotional stress in patients with symptoms of hyperthyroidism a significant reduction of triiodothyronine level was observed (from 2.59±0.07 to 1.71±0.07 nmol/l) along with the absence of changes in thyroxine level and tendency to reduction of TSH. This effect was also accompanied by a decrease in correlation index between T3 level and some definite indicators of cellular immunity. The revealed features may indicate a depletion of adaptive capacity of thyroid system caused by the prolonged effects of low doses of ionizing radiation.

Keywords: immune system; thyroid status; contamination; stress; cortisol; deconditioning

References

  1. Brenner AV, Tronko MD, Hatch M, Bogdanova TI, Oliynik VA, Lubin JH et al. I-131 dose response for incident thyroid cancers in Ukraine related to the Chornobyl accident. Environ Health Perspect. 2011;119(7):933–9. CrossRef PubMed PubMedCentral
  2.  
  3. Demidchik YE, Saenko VA, Yamashita S. Childhood thyroid cancer in Belarus, Russia, and Ukraine after Chernobyl and at present. Arq Bras Endocrinol Metabol. 2007;51:748–62. CrossRef PubMed
  4.  
  5. Popovych IL, Fliunt IS, Alieksieiev OI, Baryliak LH, Bilas VR. Sanogenetic principles of rehabilitation of urological patients of Chornobyl contingent at Truskavets resort. Kyiv: Computer press, 2003: 192 p. PubMed
  6.  
  7. Stepanova EI, Kolpakov IE, Kondrashova VG, Vdovenko VYu, Davidenko OA, Galichanskaya TY et al. Review of 15-year observations of the children health suffered as a result of the Chernobyl accident. Int J Radiat Med. 2001; 3(1–2):128.
  8.  
  9. Antipkin YG, Arabskaya LP. Peculiarities of hormonal regulation of physical development and bone tissue in children born after accident at Chernobyl Nuclear power plant. Int J Radiat Med. 2003; 5(1–2): 223–30.
  10.  
  11. Contis G, Foley T.P. Depression, Suicide Ideation, and Thyroid Tumors Among Ukrainian Adolescents Exposed as Children to Chernobyl Radiation. J Clin Med Res. 2015; 7(5): 332–38. CrossRef PubMed PubMedCentral
  12.  
  13. Filaire E, Alix D, Ferrand C, Verger M. Psychophysiological stress in tennis players during the first single match of a tournament. Psychoneuroendocrinology. 2009;34(1):150–7. CrossRef PubMed
  14.  
  15. Tafet GE, Bernadini R. Psychoneuroendocrinological links between chronic stress and depression. Prog Neuropsychopharmacol Biol Psychiatry. 2003;27(6): 893–903. CrossRef  
  16. Sokolenko VL. Impact of emotional stress on the immune system indices among residents of radiation contaminated areas. Fiziol Zh. 2016; 62(4):53–9. [Ukrainian]. CrossRef  
  17. Zhou Q, Wang H-C, Klein JR. Characterization of a novel anti-mouse thyrotropin monoclonal antibody. Hybridoma Hybridomics. 2002;21:75-9. CrossRef PubMed
  18.  
  19. Charmandari E, Tsigos C, Chrousos G. Endocrinology of the stress response. Annu Rev Physiol. 2005; 67:259–84. CrossRef PubMed
  20.  
  21. Nadolnyk LI. Stress and thyroid. Biomed Chem. 2010; 56(4): 443–56.
  22.  
  23. Ito M, Yamashita S, Ashizawa K, Namba H, Hoshi M, Shibata Y et al. Childhood thyroid diseases around Chernobyl evaluated by ultrasound examination and fine needle aspiration cytology. Thyroid. 1995;5:365–8. CrossRef PubMed
  24.  
  25. Sokolenko VL. Cellular immunity indices in people with certain thyroid status characteristics under conditions of low doses of chronic radiation exposure. Bull Probl Biol Med. 2016; 1(126): 403–5 [Ukrainian].
  26.  
  27. Kelley G. Peripheral metabolism of thyroid hormones: A review. Alternative Med Rev. 2000;5:306–33.
  28.  
  29. De Groot LJ. Dangerous dogmas in medicine: The nonthyrodial illness syndrome. J Clin Endocrinol Metab. 1999; 84:151–64. CrossRef PubMed
  30.  
  31. Fakete C, Gereben B, Doleschall M. Lipopolysaccharide induces type 2 iodothyronine deiodinase in the mediobasal hypothalamus: Implications for the nonthyroidal illness Syndrome. Endocrinology. 2004; 145:1649–55. CrossRef PubMed
  32.  
  33. Besedovsky HO, del Rey A, Sorkin E. Chanes in plasma hormone profile after tumor transplantation into syngeneic and allogeneic rats. Int J Cancer. 1985;36:209–16. CrossRef PubMed
  34.  
  35. Klein JR, Wang H-C. Characterization of a novel set of resident intrathyroidal bone marrow-derived hematopoietic cells: potential for immune-endocrine interactions in thyroid homeostasis. J Exp Biol. 2004; 207(1): 55–65. CrossRef PubMed
  36.  
  37. Wang H-C, Whetsell M, Klein JR. Local hormone networks and intestinal T cell homeostasis. Science. 1997; 275:1937–9. CrossRef  

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2019.