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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2017; 63(3): 24-31

OXIDATIVE POWER AND INTRACELLULAR DISTRIBUTION OF MITOCHONDRIA AS A REGULATOR OF CELL OXYGEN REGIME UNDER CIRCULATORY HYPOXIA

K.G.Liabakh

    International Scientific training Center for Information Technologies and Systems National Academy of Sciences, Kiev, Ukraine
DOI: https://doi.org/10.15407/fz63.03.024


Abstract

The regulatory impact of the mitochondria spatial distribution and enlargement in their oxidative power qO2 on oxygen consumption and the tissue oxygenation of skeletal muscle during circulatory hypoxia were studied. Investigations were performed by the mathematical modeling of 3D O2 diffusionreaction in muscle fiber. The oxygen consumption rate VO2 and tissue pO2 were analyzed in response to a change in muscle blood flow velocity in the range 0.012-0.950 ml ⋅ min-1 ⋅ g-1 at a moderate load. The cells with evenly (case 1) and unevenly (case 2) distributed mitochondria were considered. According to calculations due to a rise in mitochondria oxidative power it was possible to maintain everage meaning of muscle VO2 at constant level despite a decrease in O2 delivery. Minimum value of tissue pO2 was about 0 and an area of hypoxia appeared inside the cell in case 1. But hypoxia disappeared and minimum value of pO2 increased from 0 to 4 mmHg if mitochondria were distributed unevenly proportionally to VO2 gradient (case 2). It was assumed that an increase in mitochondria enzyme activity and mitochondria migration to the places of the greatest oxygen consumption rate can improve oxygen regime in the cell in terms of their adaptation to hypoxia.

Keywords: cell oxygen regime; circulatory hypoxia; adaptation; mathematical model; oxygen consumption rate; distribution of mitochondria; oxidative power of mitochondria.

Full text: (PDF, in Ukrainian)

References

  1. Li Y, Rempe D. During hypoxia HUMMR joins the mitochondrial dance. Cell Cycle. 2010; 9(1): 50–5. CrossRef PubMed
    2.  
  2. Morris R. Hollenbeck P. Axonal transport of mitochondria along microtubules and F-actin in living vertebrate neurons. J Cell Biol. 1995; 131: 1315–26. CrossRef PubMed
    3.  
  3. Zaguskin S, Zaguskina L, Zaguskina C. Intracellular regulation of oxygen consumption in the neuron crayfish stretch receptor. Cytology. 2007; 49(10): 832–8. [Russian].
    4.  
  4. Mironov S. Complexity of mitochondrial dynamics in neurons and its control by ADP produced during synaptic activity. Int J Biochem Cell Biol. 2009; 41(10): 2005–14. CrossRef PubMed
    5.  
  5. Lyabakh K. Mathematical modeling of oxygen transport in skeletal muscle during exercise: hypoxia and VO2 max. Adv Exp Med Biol. 1999; 471: 585 –93. CrossRef PubMed
    6.  
  6. Lyabakh K, Mankovskaya I. Oxygen transport to skeletal muscle working at VO2max in acute hypoxia: theoretical prediction. Comparative Biochem and Physiol, Part A. 2002; 132: 53–60. CrossRef  
  7. Lyabakh K, Mankovskaya I. Oxygen supply of human muscle at work in the mountains. Sports Med. 2008; 1: 120–6. [Russian].
    8.  
  8. Hoppeler H, Fluck M. Plasticity of skeletal muscle mitochondria: structure and function. Med Sci Sports Exerc. 2003; 35(1): 95–104. CrossRef PubMed
    9.  
  9. Liabakh K, Lissov P. Oxidative power and intracellular distribution of mitochondria control cell oxygen regime when arterial hypoxemia occurs. Biophysics. 2012; 57(5): 628–33. CrossRef  
  10. Holloszy J. Adaptation of skeletal muscle to endurance exercise and their metabolic consequences. J Appl Physiol. 1984; 56: 831–8. PubMed
    11.  
  11. Kayar S, Hoppeler H, Essen-Gustavson B, Schwerzmann K. The similarity of mitochondrial distribution in equine skeletal muscle of differing oxidative capacity. J Exp Biol. 1988; 137: 253–63. PubMed
    12.  
  12. Bizeau M, Willis W, Hazel J. Differential responses to endurance training in subsarcolemmal and intermyofibrillar mitochondria. J Appl Physiol. 1998; 85: 1279–84. PubMed
    13.  
  13. Mainwood G, Rakusan K. A model for intracellular energy transport. Can J Physiol Pharmacol.1982; 60(1): 98–102. CrossRef PubMed
    14.  
  14. Liesa M, Palacín M, Zorzano A. Mitochondrial dynamics in mammalian health and disease. Physiol Rev. 2009; 89: 799–845. CrossRef PubMed
    15.  
  15. Jing Sook Kim-Han, Jo Ann Antenor-Dorsey, O'Malley K. J. The Parkinsonian mimetic, MPP, specifically impairs mitochondrial transport in dopamine axons. Neurosci. 2011; 31: 7212–21. CrossRef PubMed PubMedCentral
    16.  

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