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OXIDATIVE POWER AND INTRACELLULAR DISTRIBUTION OF MITOCHONDRIA AS A REGULATOR OF CELL OXYGEN REGIME UNDER CIRCULATORY HYPOXIA
K.G.Liabakh
International Scientific training Center for Information Technologies and Systems National Academy of Sciences, Kiev, Ukraine
DOI: https://doi.org/10.15407/fz63.03.024
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Abstract
The regulatory impact of the mitochondria spatial distribution
and enlargement in their oxidative power qO2 on oxygen
consumption and the tissue oxygenation of skeletal muscle
during circulatory hypoxia were studied. Investigations were
performed by the mathematical modeling of 3D O2 diffusionreaction
in muscle fiber. The oxygen consumption rate VO2 and
tissue pO2 were analyzed in response to a change in muscle
blood flow velocity in the range 0.012-0.950 ml ⋅ min-1 ⋅ g-1 at
a moderate load. The cells with evenly (case 1) and unevenly
(case 2) distributed mitochondria were considered. According
to calculations due to a rise in mitochondria oxidative power
it was possible to maintain everage meaning of muscle VO2
at constant level despite a decrease in O2 delivery. Minimum
value of tissue pO2 was about 0 and an area of hypoxia
appeared inside the cell in case 1. But hypoxia disappeared
and minimum value of pO2 increased from 0 to 4 mmHg if
mitochondria were distributed unevenly proportionally to
VO2 gradient (case 2). It was assumed that an increase in
mitochondria enzyme activity and mitochondria migration
to the places of the greatest oxygen consumption rate can
improve oxygen regime in the cell in terms of their adaptation
to hypoxia.
Keywords:
cell oxygen regime; circulatory hypoxia; adaptation; mathematical model; oxygen consumption rate; distribution of mitochondria; oxidative power of mitochondria.
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© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.
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