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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2017; 63(3): 3-8


INCIDENCE OF ALLELIC POLYMORPHISMS OF GENES ENCODING SUBUNITS ATPSENSITIVE POTASSIUM CHANNELS (ILE337→VAL AND GLU23→LYS KCNJ11 GENE, AND SER1369→ALA ABCC8 GENE) IN THE UKRAINIAN POPULATION

R.B. Strutynskyi, R.A. Rovenets , О.V. Svarychevskyi, V.E. Dosenko

    O.O. Bogomoletz Institute of Physiology National Academy of Science of Ukraine, Kyiv.
DOI: https://doi.org/10.15407/fz63.03.003

Abstract

Polymorphisms of genes encoding ATP-sensitive potassium channels as risk factors for cardiovascular disease attracted the attention of researchers recently. KCNJ11 (Kir6.2) polymorphisms Ile337→Val and Glu23→Lys, and ABCC8 (SUR1) polymorphisms Ser1369→Ala was genotyped 529 volunteers in Ukrainian population by polymerase chain reaction (RTPCR) and restriction fragment length polymorphism analysis. Ile337→Val polymorphism has the next genotype distribution among 383 Ukrainian habitants: Ile/Ile in 140 persons (36.6 %), Ile/Val in 177 persons (46.2 %) and Val/Val in 66 persons (17.2 %). The frequency of genotypes Glu/Glu, Glu/Lys and Lys/Lys of polymorphism Glu23→Lys, and Ser/Ser, Ser/Ala and Ala/Ala of polymorphism Ser1369→Ala in 504 persons was 40.9 (206 subjects), 44.8 (226 subjects) and 14.3% (72 subjects) correspondingly. Inheritance of SNPs Glu23→Lys and Ser1369→Ala were linked. Thus, distribution of SNPs Ser1369→Ala and Glu23→Lys showed that it is similar to the European and close to Asian populations. The frequency of homozygote allele Ile/Ile and heterozygote allele Ile/Val of polymorphism Ile337→Val in Ukrainian population is intermediate between residents of the two aforementioned populations. However, in Ukrainian population there is a slight increase genotype Val/Val.

Keywords: allelic polymorphisms; KCNJ11; ABCC8; Ile337→Val; Glu23→Lys; Ser1369→Ala; KATP-channels

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