INCIDENCE OF ALLELIC POLYMORPHISMS OF GENES ENCODING SUBUNITS ATPSENSITIVE POTASSIUM CHANNELS (ILE337→VAL AND GLU23→LYS KCNJ11 GENE, AND SER1369→ALA ABCC8 GENE) IN THE UKRAINIAN POPULATION
R.B. Strutynskyi, R.A. Rovenets , О.V. Svarychevskyi, V.E. Dosenko
O.O. Bogomoletz Institute of Physiology National Academy of Science of Ukraine, Kyiv.
DOI: https://doi.org/10.15407/fz63.03.003
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Abstract
Polymorphisms of genes encoding ATP-sensitive potassium
channels as risk factors for cardiovascular disease attracted
the attention of researchers recently. KCNJ11 (Kir6.2) polymorphisms
Ile337→Val and Glu23→Lys, and ABCC8 (SUR1)
polymorphisms Ser1369→Ala was genotyped 529 volunteers
in Ukrainian population by polymerase chain reaction (RTPCR)
and restriction fragment length polymorphism analysis.
Ile337→Val polymorphism has the next genotype distribution
among 383 Ukrainian habitants: Ile/Ile in 140 persons (36.6
%), Ile/Val in 177 persons (46.2 %) and Val/Val in 66 persons
(17.2 %). The frequency of genotypes Glu/Glu, Glu/Lys and
Lys/Lys of polymorphism Glu23→Lys, and Ser/Ser, Ser/Ala
and Ala/Ala of polymorphism Ser1369→Ala in 504 persons
was 40.9 (206 subjects), 44.8 (226 subjects) and 14.3% (72
subjects) correspondingly. Inheritance of SNPs Glu23→Lys
and Ser1369→Ala were linked. Thus, distribution of SNPs
Ser1369→Ala and Glu23→Lys showed that it is similar to the
European and close to Asian populations. The frequency of
homozygote allele Ile/Ile and heterozygote allele Ile/Val of
polymorphism Ile337→Val in Ukrainian population is intermediate
between residents of the two aforementioned populations.
However, in Ukrainian population there is a slight increase
genotype Val/Val.
Keywords:
allelic polymorphisms; KCNJ11; ABCC8; Ile337→Val; Glu23→Lys; Ser1369→Ala; KATP-channels
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