Influence of single nucleotide polymorphisms of vitamin D receptor-gene on the level of osteoassociated hormones linkage with postmenopausal osteoporosis
D.S. Ziablitsev, O.S. Larin
Ukrainian Science-Practical Centre of Endocrine Surgery, Transplantation of Endocrine Organs and Tissues Ministry of Healthcare of Ukraine, Kyiv, Ukraine
The levels of osteoassociated hormones, macroelements, interleukines, cyclic nucleotides and activity of
alkaline phosphatase were being detected in the blood plasma of 74 postmenopausal women with and
without osteoporosis (OP). Bone mineral density (BMD) and the metacarpal index were being assessed
according to the results of densitometry. The allele polymorphisms vitamin D receptor gene (VDR) Cdx2
(rs11568820) and TaqI (rs731236) were being identified with the help of the polymerase chain reaction. The
major genotype CC TaqI was found in the group without OP 3.4 times more often than with OP, while the
minor genotype TT was found 3.4 times more often with the presence of OP. The presence of the genotype
CC TaqI decreased the risk of OP progress by 5.5 times, and the genotype TT TaqI increased by 5.4 times.
The presence of the minor allele T was associated with the higher levels of interleukin 1β, BMD and lower
testosterone blood level. The major homozygote AA Cdx2 was found in women without OP 2.9 times more
often, while the minor genotype GG – 5.4 times more often with the presence of OP. The presence of the
major homozygote decreased the risk of OP progress by more than 5.3 times, while the minor homozygote
increased the risk by 8 times. The presence of the minor allele G in the genotype was associated with the increase of parathyroid hormone, phosphorus, magnesium, alkaline phosphatase activity in blood, BMD and with the decrease of testosterone, progesterone and calcium blood levels.
postmenopausal osteoporosis: hormones: VDR: polymorphism Cdx2 (rs11568820): polymorphism TaqI (rs731236)
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