It was shown that acute (7% of oxygen in nitrogen, 30-60 min) and chronic hypoxic hypoxia (adaptation to the conditions of the middle mountains 2100 m above sea level) increased hemoglobin contents and organic phosphates--2,3-DPG and ATP in Wistar rats. Preliminary administration of taurine, taurile, ionole in normal and hypoxic conditions had no essential effect on the oxygen blood capacity where as the content of 2,3-DPG and glucoso-6-phosphate dehydrogenase activity increased. Taurin was more effective, than tauril.