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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 1999; 45(1-2): 72-79


The effect of L-arginine on the ultrastructure of atrial cardiomyocytes in experimental hypercholesterolemia

Stechenko LO, Sahach VF, Tkachenko MM, Skybins'ka TR, Andriienko TV.

    A. A. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kiev


Abstract

The results of electronmicroscopic study of the right atrium in experimental hypercholesterolemia revealed a disturbance of ultrastructural organisation of both cardiomyocytes and endothelial cells of blood microvessels. Intake of L-arginine--a precursor of synthesis of nitric oxide (NO)--with atherogenic diet was found to prevent to some extent the damage of ultrastructural organisation of cardiomyocytes and to stimulate the production of atrial granules. A significant number of secretory components, which differ in terms of structure and function, revealed in the endothelium of blood microvessels may testify to the fact that upon administration of L-arginine the paracrine effect of hormonal regulation is enhanced manifesting itself through an increase of synthesis and secretion of natriuretic hormone in atrial cardiomyocytes. A tissue hormonal system is displayed through an increase of synthesis and secretion of atrial natriuretic hormone in cardiomyocytes. On the other hand, a NO precursor L-arginine may produce a correcting effect upon the ultrastructure of endotheliocytes in hypercholesterolemia.

References


© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2019.