Українська English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 1999; 45(1-2): 56-63

The interrelation of neural and humoral cardiogenic influences and their action on the blood circulation

Pavliuchenko VB

    O. O. Bogomoletz Institute of Physiology, NAS, Kiev


The role of some endogenous bioregulators in formation of cardiogenic reflectory effects on circulation were investigated in acute experiments on anesthetized animals with using various methods (direct recording of impulse activity from cardiac afferent nerves, humoral isolation of the heart). Interrelations between development of cardiogenic depressor reactions and nitric oxide production was established. Systemic inhibition of NOS led to decrease in dilatation of coronary and peripheral vessels. At the other hand dramatic suppression of cardiogenic depressor reflexes followed by inhibition of prostacyclin production. The data support the essential role of endogenous bioactive substances in formation of cardiogenic reflex effects on circulation in physiological and pathological states. We also suggest that a mayor metabolite of arachidonic acid--prostacyclin--is modulator and one of humoral components of the vagus-mediated cardiogenic depressor reflex in physiological conditions.


© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.