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The effect of shear stress on vascular endothelium
Marchenko SM
Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kiev
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Abstract
Effects of shear stress on intracellular Ca2+ concentration ([Ca2+]i) and membrane potential of intact endothelium of the rat aorta have been investigated. Shear stress and acethylcholine both evoked endothelium-dependent relaxation of the rat aorta, but in contrast to acethylcholine shear stress did not affect [Ca2+]i and membrane potential of the endothelium. These data do not corroborate the hypotheses on involvement of Ca2+ and membrane potential in reception of shear stress by endothelium.
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© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.
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