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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 1999; 45(1-2): 35-39


The effect of membrane channel agonists and antagonists on hemodynamics and vascular tonus

Shevchuk VH, Iahupol's'kyĭ LM, Shavaran SS, Klebanov BM, Zyma SV.

    National Medical University, Kiev


Abstract

Compound "C" which was synthesized in Institute of Organic Chemistry NA of Science unite in one molecule remnant of 4-aril-1,4-dihydropyridin kernek cause it as calcium channel block-up property and group of molecule pinacidil which determine if effect as activation potassium channels. This compound cause essential decrease arterial pressure and total periphery resistance of vessels. The decrease this figures of hemodynamic connect with reducing vessels tone. This is proved by substantial decrease contractile activity isolated strips of aorta and portal vein by compound "C". The mechanism reducing tone, as demonstrate investigations on isolated solitary smooth muscle mesenterial arteries, cause with increase potassium current, hyperpolarization of cell's membrane, and with depresses calcium current in L-type Ca(2+) channels.

References


© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2019.