The effect of a grape extract on the contractile activity of the myocardium and on the coronary flow of the isolated guinea pig heart
Sahach VF, Shymans'ka TV, Zul'fiharov OS, Ovchynnikova OH, Hozhenko AI.
A. A. Bogomolets Institute of Physiology, National Academy of Science of Ukraine, Kiev
Effects of one of the fraction of grape extract on myocardial contractility and coronary flow of isolated guinea pig heart have been investigated. It was shown that the administration of grape extract led to myocardial contractility index is increase by 77%, coronary flow increase by 13% and oxygen consumption increase by 30%. Inhibition of nitric oxide synthesis by L-NMMA resulted in decrease of grape extract-induced coronary flow increase. These data support of isolated strips investigation that grape has a compounds which induced endothelium-dependent vasodilation of coronary bed. They indicate that these substances have the strong cardiostimulating effect