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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 1999; 45(5): 80-84

The reaction of regenerating connective tissue to acetylcholine in the dynamics of the denervation-reinnervation process

Prosha MV.

    A. A. Bogomolets National Medical University, Kiev


The granulation tissue of wounds on upper surface of feet on the 7th day under repeated acetylcholine (Ach) application (0.02 g/1) was studied. In the control group, Ach-induced intensification of inflammatory process and bad condition of regenerating tissue of skin. This pathological reaction increased (fastly appeared ulceration) at once after crushing of right sciatic nerve in the denervated wound. It was less pathological in the contralateral (innervated) wounds. The effect of ACh was positive on later term of neurodystrophic process in the denervated wound and in the contralateral one. Cholinoceptive of granulation tissue of bilateral wound became normal after reinnervation.


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