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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 1999; 45(5): 60-67

The balance of elastase and its inhibitors in the vascular tissues of rabbits of different ages in the early stages of experimental Mönckeberg-type arteriosclerosis

Dosenko VIe

    A. A. Bogomolets National Medical University, Kiev


The role of the elastolytic system in pathogenesis of vascular diseases was investigated on adult and one-month old rabbits in experimental ergocalciferol-induced media calcinosis depending on age aspect. The obtained results indicate that elastase activity was increased in aortic homogenates of one-month old rabbits but not in adult animals. The level of alpha 1-proteinase inhibitor is reduced in one-month old rabbits, and decrease of the alpha 2-macroglobulin content in arterial walls occurs in adults. A higher level of antielastase proteins in both groups of animals in venous vessels is determined. After effect of ergocalciferol in the veins of one-month-old rabbits, differs from the adults, a significant increase of the inhibitor content is observed. The presented results confirm the importance of balance between elastase and it inhibitors in pathogenesis of arteriosclerosis.


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