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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 1999; 45(5): 3-8

The effect of annexins on the contractile activity of the smooth muscles in the rat portal vein

Sahach VF, Andrukhov OIa, Babiĭchuk EB, Babiĭchuk VS, Danylova VM, Draeger A.

    A. A. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kiev


This study examines the effects of the family of calcium-dependent phospholipids binding proteins (annexins) on the contractile properties of rat portal vein. We developed the new method of annexin's purification from pig stomach muscle. It found that in nanomolar concentrations annexins caused dose-dependent effects on phasic and tonic component of rat portal vein contractile activity. The frequency of spontaneous contractions was increased whereas the amplitude was decreased. At the same time we observed the rise of basal tone level of contractions. We suggested that annexins may change the contractile properties of vascular smooth muscle.


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