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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 1999; 45(4): 105-110

The effect of nitric oxide donors on the respiratory rhythm of an artificially superfused preparation of the brain of newborn rats

Volhin DV, Volhina AV, Seredenko MM.

    A. A. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kiev


The influence of an exogenous nitric oxide (NO) donor, sodium nitroprusside, and endogenous NO biosynthesis substrate, L-arginine, on integrated respiratory rhythm recorded from the phrenic nerve of the semi-isolated medullo-spinal preparations of the 3-to-4-days old rats was studied. Applications of 10.0 mcM of these drugs led to significant increase in the duration and amplitude of the inspiratory discharges (ID) in the phrenic nerve and to decrease of ID frequency. After the rostral ventrolateral (RVL) medulla (projectionally corresponds to "M" chemosensitive zone) had been separated by transection, such applications began to evoke a rise of ID frequency without significant changes of the duration and amplitude. Thus, we found the involvement of NO in the tonic inhibition of the respiratory rhythm by RVL medullary structures in the neonatal rats.


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