Українська English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 1999; 45(4): 35-40

The action of pilocarpine on the accommodation properties of isolated phasic neurons of the rat hippocampus

Luk'ianets' OO1, Iavors'kyĭ VA

    A. A. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kiev


Using of voltage and current clamp methods in conditions of perforated membrane fragment, we investigated the accommodation properties of isolated neurones from different zones of hippocampus. The investigated neurones could be separated into two main groups concerning their responses to prolonged pulses of suprathreshold depolarization--neurones which after generation of several action potentials (AP) stopped their generation (phasic, F-neurones), and (tonic, T-neurones), which did not accommodate and continued AP generation during entire depolarizing pulse. Comparison of ionic current composition in neurones of both groups has shown, that T-neurones demonstrate more expressed inactivation of outward currents that can be due to the presence of a fast inactivating A-type potassium current, or decreased inactivation of inward currents. Pilocarpine, well-known epileptogenic compound increased accommodation and induced significant slow-down of outward current inactivation in F- neurones. It can be suggested that the presence of A-type potassium current and/or a slowly inactivating component of inward current can play main role in determining the accommodation effect in hippocampal neurones.


© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2023.