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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 1999; 45(4): 27-34

Volume-sensitive anion conductivity in a human prostatic carcinoma cell line

Shuba IaM, Skryma RN, Prevars'ka NB

    A. A. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine


For the first time membrane anion current activated in response to the cell swelling following exposure to hypotonic solution has been found in human prostate carcinoma cell line LNCaP. The development of hypotonicity-evoked current required 5 to 10 min to the maximum and was almost completely reversible upon return to the solution with normal osmolarity. Not absolute selectivity for Cl- ions of the respective cell volume-sensitive channels has been shown.


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