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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 1999; 45(3): 61-68

The effect of the lysosomal function of circulating neutrophils on hemostasis and on the morphological changes in the internal organs in the disseminated intravascular coagulation syndrome

Koval' SB1, Boiarchuk OD, Lunina NV.

    A. A. Bogomolets Institute of Physiology, NAS Ukraine, Kiev


Development of experimental the syndrome of disseminated intravascular coagulation, DIC syndrome, in organism laboratory animals from affect preparation "EFA-2" by accompanied increase quantity of neutrophiles circulations, modifications of the lysosomal apparatus of neutrophiles the activity of the serum acid phosphatase increased, characteristic damage on hemostasis system and typical alteration in some organs. As a result limitation of number of neutrophiles was achieved of suppression, of granulocytopoiesis by means "Myelosan" pharmacy, did not increase activity in blood serum solution lysosomal enzyme of neutrophils and not development in organism DIC syndrome. Made conclusion, the neutrophils have influence of promotion generalization DIC syndrome.


© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.