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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 1999; 45(3): 43-51

The species characteristics of the elastolytic system of the arteries and veins in the early stages of experimental tunica media calcinosis and atherosclerosis

Dosenko VIe

    A. A. Bogomolets National Medical University, Kiev


The role of the elastolytic system arterial and venous tissues in pathogenesis of vascular pathology was investigated on rabbits and rats in experimental arterio-atherosclerosis. The obtained results indicate that elastase activity in aortic homogenates was significant higher in normal and pathological condition in rats than in rabbits. Elastase inhibitors (alpha 2-macroglobulin and alpha 1-proteinase inhibitor) also respond on angiosclerotic agent and level of alpha 2-macroglobulin increased significant in resistant animals (rats) but not in rabbits. In venous vessels determined more higher level of antielastase potential that may be explain its phenomenal resistance to different damage factors. The presented result confirm the importance of balance elastase and it inhibitors in pathogenesis of arterio-atherosclerosis.


© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.