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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 1999; 45(3): 28-34

Antibodies depress the meiotic oocyte maturation of mice in vitro

Hotsuliak IaM, Ianchiĭ RI.

    A. A. Bogomoletz Institute of Physiology, NAS, Ukraine


Experiments on mouse of the CBA line have shown that polyclonal antiovarian and specific to oolemma monoclonal antibodies depress meiotic maturation of oocytes in vitro and potentially can be the reason for the female infertility. Changes in electrogenic properties and Ca2+ channels of oolemma are likely to be in the base of the mechanisms of depressing action of antibodies on meiotic maturation.

Keywords: Antibodies, meiotic oocyte maturation, mice


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