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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2017; 63(2): 80-85

PHAGOCYTIC ACTIVITY OF NEUTRHOPHILS IN PATIENTS WITH SYSTEMIC SCLEROSIS AND LUNG INJURY

V. Hayevska, V. Hayevskyy, O. Kovalyshyn

    Lviv National Medical University named by Danylo Halytskyy
DOI: https://doi.org/10.15407/fz63.02.080


Abstract

We evaluated spontaneous phagocytic activity of monocytes and the reserved capacity of neutrophils in patients with systemic sclerosis with pulmonary injury of various kinds: pneumofibrosis and pulmonary hypertension. We found that among patients with systemic sclerosis, lung injury was observed in 71.6%, including 52.8% with pneumofibrosis, 11.4% with pulmonary hypertension and 35.8% with a combination of these pathologies. Analysis of phagocytic system in the groups of patients showed: an increased spontaneous neutrophil phagocytic activity in patients with systemic sclerosis and lung damage, which is 33.3% higher as compared to patients with systemic sclerosis without lung damage. These changes are more pronounced in patients with a combination of pneumofibrosis and pulmonary hypertension (P <0.001). At the same time, reducing the backup of phagocytic ability of monocytes were found in patients with systemic sclerosis and pneumofibrosis, which is 37.8% lower as compared with patients with combination of pneumofibrosis and pulmonary hypertension, and 21.1% lower in patients with pulmonary hypertension. Thus, studies of phagocytosis of neutrophils and monocytes gave us the opportunity to identify groups of patients with systemic sclerosis without damaging the lungs to group of the patients with initial changes in lung tissue, later verified by computer tomography (19.1%).

Keywords: systemic sclerosis; lung damage; phagocytosis.

Full text: (PDF, in Ukrainian)

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