We examined the effect of germanium citrate on immunophysiological mechanisms of homeostatic reactions of rats of different ages and physiological states. We show that daily exposure of female rats to germanium citrate obtained by nanotechnology (groups 2-4) and chemical synthesis (groups 5-6) in the doses of 10 (group 2), 20 (group 3), 200 (group 4 and 5) and 2000 (group 6) mcg/kg resulted in immunophysiological changes in animals of all research groups. In the blood of female rats after 4 months of germanium intake, and infant male rats of groups 5 and 6 at 60-65 days of life, the concentration of immunoglobulins significantly increased by 1.73 – 2.45 times (females) and 1.05 – 1.1 times ( males). The concentration of circulating immune complexes increased by 1.12 – 3.10 and 1.27– 2.02 times, sialic acids by 1.01 – 1.54 and 1.39 – 1.59 times; hexoses bound to proteins by 1.12 – 1.17 and 1.20 – 1.33 times in groups 5 and 6. In all rats, the level of average molecular weight was reduced by 6 – 17 %, platelet count by 22 – 39 % in females and 6 – 23 % in males, and phagocytic activity by 5.3 – 10.2% and 4.4 – 5.7%, respectively, which points to the same direction of the immunobiological action of germanium citrate in adult and young rats of both sexes. We also found a reduction in the concentration of ceruloplasmin and the number of white blood cell in the blood of female rats of research groups 3 – 4 and their growth in males of groups 2– 4. Studying the state of the immune system and content of glycoproteins in the blood, we analyzed the immunophysiological characteristics of influence of low and high doses of germanium citrate depending on the duration of its intake, as well as systemic communication of the mother and fetus. The data indicate for the sex and age specific features of hepato- immunological communication in the organism of these animals under prolonged germanium citrate load. The biological effect is more pronounced in rats treated with 20 and 200 mcg of germanium.