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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2001; 47(5): 12-17


Age features of functioning of nervous - muscularsystem of rats in conditions hyperthyroidism

P.A. Nerush, E.A. Makii, A.G. Rodinsky

    Dnepropetrovsk State Medical Аcademy, Ministryof Health of Ukraine


Abstract

Studied features of functioning of nervous - muscular system at white rats of two age groups: preadolescent (5 weeks) and pubiral (24 weeks), in conditions expe- rimental hyperthyroidism (HT). It is established, that in conditions HT at action of the raised concentration thyroxine characteristics of excitation gastrocnemius muscles essentially changed at irritation of a sciatic nerve in groups preadolescent and puberal animals. In all age groups in conditions HT increase of a thres- hold of excitation gastrocnemius muscles is marked at indirect stimulation and decrease at direct sti- mulation; also in all age groups in conditions HT reduction of time chronaxy muscles is fixed, both at direct, and at indirect irritation. At preadolescent animals, as against puberal in conditions HT at action of the raised concentration thyroxine on nervous - muscular system it is not revealed authentic change of the latent period and amplitude of potential of action (PA). The conclusion is made, that in con- ditions HT change of a threshold of excitation and chronaxy gastrocnemius muscles both at direct, and at indirect irritation do not carry age specificity and have an identical orientation, both at preadolescent, and at puberal rats. At preadolescent animals in conditions HT, as against puberal the parameter of amplitude and latent period PA authentically did not change, that can testify to smaller sensitivity of the caused answers gastrocnemius muscles to the raised concentration thyroxine, probably, by virtue of imma- turity peripheral neuromotor the device.

References

  1. СПИСОК ЛІТЕРАТУРИ
  2. Неруш П.О., Макій Є.А., Краюшкіна І.А., Ро- динський О.Г. Патогенез двигательных рас- стройств при тиреотоксикозе / /Фізіол.журн. - 1998. - 44, №3. -С. 47-48.
  3. 5 № ,74 .Т ,1002 ,.нруж .лоізіФ 9848-1020 NSSI17 Матеріал надійшов до редакції 9.01.2001 Дніпропетров. мед. академія М-ва охорони здоров’я України П.О.Неруш та ін.
  4. Лакин Г.Ф. Биометрия. – М.: Высш. школа, 1990. - 351 с.
  5. Макій Є.А., Неруш П.О., Родинський О.Г. и др. Особенности возбудимости вентральных кореш- ков спинного мозга белых крыс при прямой сти- муляции в условиях длительного воздействия тироксина // Вісн. Дніпропетров. ун-ту. - 2000. - С. 62-65.
  6. Гольбер Л.М., Гайдина Г.А., Игнатков В.Я., Алиев М.Н. Аномально підвищені відповіді спин- ного мозку, викликані дією тироксину, тиролі- берину або 4-амінопіридину / Под ред. Гольбе- ра Л.М. – М.: Медицина, 1980. - 208 с.
  7. Сытник С.И., Стожаров А.Н., Воронецкий Б.К. Функциональное состояние тиреоидной системы детей, облученных внутриутробно в результате Чернобыльской катастрофы // Пробл. эндок- ринологии. – 1999. - 45, №1. - С. 26-29.
  8. Berlit P., Mahlberg U., Usadel K.H. Zur Frage der Pollyneuropathie bei Hyperthyreose - neine klinisch-neurophysiologische Stude // Schweiz. Arch. Neurol. und Psychiat. - 1992. №1. - P. 81-90.
  9. Brodie C., Sampson S.R. Characterization of thy- roid hormone effects on Na channel synthesis in cultured skeletal myotubes: role of Ca2+ myotubes // Endocrinology.-1989.- № 2. -P. 842- 849.
  10. Brodie C., Sampson S.R. Characterization of thyroid hormone effects on membrane potential and Na-K pump in cultured rat skeletal myotubes. - In: Neuromuscular Function. – Amsterdam etc, 1989. – P. 585.
  11. 9. Brodie C., Sampson S.R. Characterization of thy- roid hormone effects on Na-K pump and membrane potential of cultured rat skeletal myotubes // Endocrinology. - 1988. - № 2. - P. 891- 897.
  12. 10. Brant H.J., Eng S.P. Klein L.E. et al. Effects of triiodthyronine on resting membrane potential of primary cultured rat submandibular gland cells // Cell Biol. Int. Repts. – 1988. - №12. – P. 1027-1036.
  13. Caroccia L., Williams D.A., Wrigth A. et al. Effects of thyroid and parathyroid hormones on muscular activity // Proc. Austral. Physiol. and Phar- macol. Soc. – 1988. – P. 71.
  14. Everts M.E., Clausen T. Effects of thyroid hormone on Na + - K+ transport in resting and stimulated rat skeletal muscle // Amer. J. Physiol. – 1988. - 255, №5. – P. 604-612.
  15. Hofmann W.W., Denis E.H. Effect of thyroid hormone at the neuromuscular junction // Ibid. - 1972 - №2. - P. 283-287.
  16. Michalak M., Fliegel L., Burns K. et al. The thy- roid hormone receptor of sarcoplasmic reticulum membranes // J. Mol. and Cell. Cardiol. – 1989. - №3. – P. 19.

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