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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2017; 63(2): 40-45


Dynamics of proinflammatory cytokines at phlegmons of the maxillofacial area

U.D. Matolych, O.Z. Masna-Chala, L.Y. Lapovets, B.V. Dzhuran

    Danylo Halytsky Lviv National Medical University, Ukraine
DOI: https://doi.org/10.15407/fz63.02.040

Abstract

Despite the continuous improvement of diagnosis and treatment, phlegmons of the maxillofacial area is one of the first places in the clinic of maxillofacial surgery. The concentrations of proinflammatory cytokines 6, 8, 17 were estimated in the serum of patients with this pathology with different spread of inflammation in the dynamics of treatment. It is shown that the level of cytokines in the patients under research was higher than in the control group. It is established that maintaining high concentrations of interleukin-6 (IL-6, 14.6–34.8 ng/l), IL-8 (17.3–26.8 ng/l), IL-17 (17.0–20.9 ng/l) during the treatment period (9 days) leads to complications, progression of inflammatory processes. Thus, excessive production of cytokines leads to the appearance of severe pathological conditions in a human body. During the treatment, a strong direct correlation between IL-6 and IL-17, and IL-8 and IL-17 was established which may indicate a combined synergistic effect of the studied cytokines. Evaluation of the level of the cytokines during the disease can be important for determining treatment strategy of patients with phlegmons of the maxillofacial area.

Keywords: phlegmons of the maxillofacial area; interleukin-6; interleukin-8; interleukin-17

References

  1. Kabanova AA, Pohodenko-Chudakova IО. Inflammatory processes of maxillofacial area and neck. Modern approach to the diagnosis, prognosis and treatment. Mil Med. 2013; 3: 125–9.
  2.  
  3. Flynn TR. Anatomy and surgical therapy of oral and maxillofacial infections. J Oral Maxillofac Surg. 2004; 62: 86–7. CrossRef  
  4. Matolych UD, Lapovets LE, Horhota AI. Dynamics of cellular immunity in patients with maxillofacial phlegmons. Lab Diagn East Eur. 2015; 1(13): 103–9.
  5.  
  6. Morozova MN, Krasnikov VO, Viborniy VG. Evaluation of the seventy of patients condition in cases of odontogenous phlegmons of the maxillofacial area and making the prognosis for their treatment. Vis Stom. 2009; 2: 64–9. [Ukrainian].
  7.  
  8. Durnovo EA, Vysel'tseva YuV, Mishina NV, Khomutinnikova NE, Marochkina MS. Peculiarities of clinicoimmunological diagnostics of common inflammatory disease of the soft tissues in the maxillofacial region and their complications. Russ J Dentist. 2012; 3: 22–6.
  9.  
  10. Matolych UD, Kaminsky VI, Kaminsky VV. The analysis of inflammatory diseases of the soft tissues of the maxillofacial area. Coll Scient Pap Inst Dent Shupyk Nat Med Acad Postgrad Educ. 2014; 5: 7–9. [Ukrainian].
  11.  
  12. Serebrennikova S, Seminskу I. The role of cytokines in the inflammatory process. Siber Med J. 2008; 8: 5–8.
  13.  
  14. Akhmedov GD. Evaluation of the cytokine status in patients with infectious and inflammatory complications of surgical interventions in the oral cavity. Dental Inst. 2012; 1(54): 82–3.
  15.   Nikitin YeV, Chaban TV, Servetsky SK. Modern notions about system of cytokines. Infect Dis. 2013; 2: 64-9. [Ukrainian]  
  16. Kologrivova IV, Kologrivova YeN, Suslova TYe. Molecular aspects of the T-helpers type 17 functioning. Bull Sib Med. 2011; 4: 93-8.
  17.  
  18. Hirata T, Osuga Y, Hamasaki K. Interleukin (IL)-17A Stimulates IL-8 Secretion, Cyclooxygenase-2 Expression, and Cell-Proliferation of Endometriotic Stromal Cells. Endocrinology. 2008; 149(3): 1260–7. CrossRef PubMed
  19.  
  20. Ketlinsky SA. Тh 17 - a new line of differentiation of T helper cells: a review of the data. Cytokines Inflamm. 2009; 8(2): 24–39.
  21.  
  22. Chang SH, Dong C. A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses. Cell Res. 2007; 17(5): 435–40.
  23.  
  24. Jin W, Dong C. IL-17 cytokines in immunity and inflammation. EMI. 2013; 2(9): 52–60. CrossRef  
  25. Scheller J, Chalaris A, Schmidt-Arras D, Rose-John S. The proinflammatory properties of the cytokine interleukin-6. BBA-Molecul Cell Res. 2011; 1813(5): 878–88.
  26.  
  27. Yamamoto K, Rose-John S. The biology of interleukin-6. Clin Pharmacol Ther. 2012; 91: 574–6. CrossRef PubMed
  28.  
  29. Allen T, Kurdowska A. Interleukin 8 and Acute Lung Injury. Lab Med. 2014; 138(2): 266–9. CrossRef

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