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Dynamics of proinflammatory cytokines at phlegmons of the maxillofacial area
U.D. Matolych, O.Z. Masna-Chala, L.Y. Lapovets, B.V. Dzhuran
Danylo Halytsky Lviv National Medical University, Ukraine
DOI: https://doi.org/10.15407/fz63.02.040
Abstract
Despite the continuous improvement of diagnosis and treatment, phlegmons of the maxillofacial area is one
of the first places in the clinic of maxillofacial surgery. The concentrations of proinflammatory cytokines 6,
8, 17 were estimated in the serum of patients with this pathology with different spread of inflammation in
the dynamics of treatment. It is shown that the level of cytokines in the patients under research was higher
than in the control group. It is established that maintaining high concentrations of interleukin-6 (IL-6,
14.6–34.8 ng/l), IL-8 (17.3–26.8 ng/l), IL-17 (17.0–20.9 ng/l) during the treatment period (9 days) leads
to complications, progression of inflammatory processes. Thus, excessive production of cytokines leads to
the appearance of severe pathological conditions in a human body. During the treatment, a strong direct
correlation between IL-6 and IL-17, and IL-8 and IL-17 was established which may indicate a combined
synergistic effect of the studied cytokines. Evaluation of the level of the cytokines during the disease can be
important for determining treatment strategy of patients with phlegmons of the maxillofacial area.
Keywords:
phlegmons of the maxillofacial area; interleukin-6; interleukin-8; interleukin-17
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© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.
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