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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2017; 63(2): 40-45

Dynamics of proinflammatory cytokines at phlegmons of the maxillofacial area

U.D. Matolych, O.Z. Masna-Chala, L.Y. Lapovets, B.V. Dzhuran

    Danylo Halytsky Lviv National Medical University, Ukraine


Despite the continuous improvement of diagnosis and treatment, phlegmons of the maxillofacial area is one of the first places in the clinic of maxillofacial surgery. The concentrations of proinflammatory cytokines 6, 8, 17 were estimated in the serum of patients with this pathology with different spread of inflammation in the dynamics of treatment. It is shown that the level of cytokines in the patients under research was higher than in the control group. It is established that maintaining high concentrations of interleukin-6 (IL-6, 14.6–34.8 ng/l), IL-8 (17.3–26.8 ng/l), IL-17 (17.0–20.9 ng/l) during the treatment period (9 days) leads to complications, progression of inflammatory processes. Thus, excessive production of cytokines leads to the appearance of severe pathological conditions in a human body. During the treatment, a strong direct correlation between IL-6 and IL-17, and IL-8 and IL-17 was established which may indicate a combined synergistic effect of the studied cytokines. Evaluation of the level of the cytokines during the disease can be important for determining treatment strategy of patients with phlegmons of the maxillofacial area.

Keywords: phlegmons of the maxillofacial area; interleukin-6; interleukin-8; interleukin-17


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