Українська Русский English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2017; 63(2): 25-33


The interactions between the cholinergic and catecholaminergic systems - focusing on memory and oxidative stress

A. Ciobica1,2,3, R. Lefter2, B. Stoica4

  1. Department of Research, Faculty of Biology, Alexandru Ioan Cuza University, Iasi, Romania;
  2. Romanian Academy, Iasi, Romania;
  3. The Academy of the Romanian Scientists, Romania;
  4. “Grigore T. Popa” University of Medicine and Pharmacy, Romania
DOI: https://doi.org/10.15407/fz63.02.025

Abstract

We analyzed the effect of various cholinergic and catecholaminergic agonists on working and reference memory in rats, as well as their relevance in the basal antioxidant and lipid peroxidation markers modifications. Adult male Wistar rats were used. They were injected with pilocarpine (cholinergic muscarinic agonist, 8 mg/kg bw,i.p.), clonidine (α2 noradrenergic agonist, 0.5 mg/kg bw,i.p.) and pergolide (general dopaminergic agonist, 0.3 mg/kg bw,i.p.). The rats were divided into 5 groups, as follows: pilocarpine+clonidine, pilocarpine+pergolide, clonidine+pergolide and pilocarpine+clonidine+pergolide, plus a control group. Behavioral testing was done through radial arm maze, while the biochemistry included the assessing of some enzymes of antioxidant defense such as superoxide dismutase and glutathione peroxidase, as well as malondialdehyde, lipid oxidation maker, in the frontal lobes. The administration of the agonists revealed a positive effect on the working and reference memory manifested through the significant decreasing in the number of errors in the radial-arms-maze-task. Moreover, combined administration of all three agonists resulted in a synergistic stimulation of spatial memory. The levels of superoxide dismutase and glutathione peroxidase activities were increased in rats treated with cholinergic and catecholaminergic agonists, while the malondialdehyde levels were decreased. These findings further support a role of interaction between catecholamines and acetylcholine in the modulation of memory processes and basal oxidative stress markers, thus having an increased relevance for the studies regarding the cognitive decline and some neuropsychiatric disorders.

Keywords: cholinergic agonist; catecholaminergic agonist; memory; oxidative stress markers; rat

References

  1. Anghelescu A, Ionescu I, Stănescu V. Memory. Bucharest, Science Editing Publication; 2001. p. 2-46.
  2.  
  3. Freeman WH. Molecular cell biology 5th edition. London, Freeman Press. 2003. p. 292.
  4.  
  5. Simionescu V, Baltag D. Neurotransmitters. Iasi, Noel Publishing, 2000. p. 1-82.
  6.  
  7. Webster R.A. Neurotransmitters, Drugs and Brain Function. London, John Wiley & Sons. 2005. p. 5-67.
  8.  
  9. Balmus IM, Ciobica A, Antioch I, Dobrin R, Timofte D. Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches. Oxid Med Cell Longev. 2016;2016:3975101. CrossRef PubMed PubMedCentral
  10.  
  11. Padurariu M, Ciobica A, Lefter R, Serban IL, Stefanescu C, Chirita R. The oxidative stress hypothesis in Alzheimer's disease. Psychiatr Danub. 2013; 25: 401-9. PubMed
  12.  
  13. Choi Y, Novak JC, Hillier A, Votolato NA, Beversdorf DQ. The effect of alpha-2 adrenergic agonists on memory and cognitive flexibility. Cogn Behav Neurol. 2006; 19: 204-7. CrossRef PubMed
  14.  
  15. Bammer G. Pharmacological investigations of neurotransmitter involvement in passive avoidance responding: a review and some new results. Neurosci Biobehav Rev. 1982; 6: 247-96. CrossRef  
  16. Mehta MA, Riedel WJ. Dopaminergic enhancement of cognitive function. Curr Pharm Des. 2006; 12: 2487-500. CrossRef  
  17. Brusa L, Tiraboschi P, Koch G, Peppe A, Pierantozzi M, Ruggieri S, Stanzione P. Pergolide effect on cognitive functions in early-mild Parkinson's disease. J Neural Transm. 2005; 112: 231-7. CrossRef PubMed
  18.  
  19. Levin ED, Rose JE. Acute and chronic nicotinic interactions with dopamine systems and working memory performance. Ann N Y Acad Sci. 1995; 757: 245-52. CrossRef  
  20. Schade R, Andersohn F, Suissa S, Haverkamp W, Garbe E. Dopamine agonists and the risk of cardiac-valve regurgitation. N Engl J Med. 2007; 356: 29-38. CrossRef PubMed
  21.  
  22. Zanettini R, Antonini A, Gatto G, Gentile R, Tesei S, Pezzoli G. Valvular heart disease and the use of dopamine agonists for Parkinson's disease. N Engl J Med. 2007; 356: 39-46. CrossRef PubMed
  23.  
  24. Ono S, Hirai K, Tokuda E. Effects of pergolide mesilate on metallothionein mRNAs expression in a mouse model for Parkinson disease. Biol Pharm Bull. 2009; 32: 1813–1817. CrossRef PubMed
  25.  
  26. Camacho F, Smith CP, Vargas HM, Winslow JT. Alpha 2-adrenoceptor antagonists potentiate acetylcholinesterase inhibitor effects on passive avoidance learning in the rat. Psychopharmacology. 1996; 124: 347-354. CrossRef PubMed
  27.  
  28. Micale V, Incognito T, Ignoto A, Rampello L, Spartà M, Drago F. Dopaminergic drugs may counteract behavioral and biochemical changes induced by models of brain injury. Eur Neuropsychopharmacol. 2006; 16: 195-203. CrossRef PubMed
  29.  
  30. Freitas RM, Nascimento VS, Vasconcelos SM, Sousa FC, Viana GS, Fonteles MM. Catalase activity in cerebellum, hippocampus, frontal cortex and striatum after status epilepticus induced by pilocarpine in Wistar rats. Neurosci Lett. 2004; 365: 102-107. CrossRef PubMed
  31.  
  32. Schwarz J. Rationale for dopamine agonist use as monotherapy in Parkinson's disease. Curr Opin Neurol. 2003; 16: 27-33. CrossRef  
  33. Tejada S, Roca C, Sureda A, Rial RV, Gamundí A, Esteban S. Antioxidant response analysis in the brain after pilocarpine treatments. Brain Res Bull. 2006; 69: 587-92. CrossRef PubMed
  34.  
  35. Tejada S, Sureda A, Roca C, Gamundí A, Esteban S. Antioxidant response and oxidative damage in brain cortex after high dose of pilocarpine. Brain Res Bull. 2007; 71: 372-5. CrossRef PubMed
  36.  
  37. Dal-Pizzol F, Klamt F, Vianna MM, Schröder N, Quevedo J, Benfato MS, Moreira JC, Walz R. Lipid peroxidation in hippocampus early and late after status epilepticus induced by pilocarpine or kainic acid in Wistar rats. Neurosci Lett. 2000; 291: 179-82. CrossRef  
  38. Erb S, Hitchcott PK, Rajabi H, Mueller D, Shaham Y, Stewart J. Alpha-2 adrenergic receptor agonists block stress-induced reinstatement of cocaine seeking. Neuropsychopharmacology. 2000; 23: 138-50. CrossRef  
  39. Jonas JC, Guiot Y, Rahier J, Henquin JC. Haeme-oxygenase 1 expression in rat pancreatic beta cells is stimulated by supraphysiological glucose concentrations and by cyclic AMP. Diabetologia. 2003; 46: 1234-44. CrossRef PubMed
  40.  
  41. Stefanescu C, Ciobica A. The relevance of oxidative stress status in first episode and recurrent depression. J Affect Disord. 2012 Dec 20;143(1-3):34-8. CrossRef PubMed
  42.  
  43. Ciobica A, Padurariu M, Dobrin I, Stefanescu C, Dobrin R. Oxidative stress in schizophrenia - focusing on the main markers. Psychiatr Danub. 2011 Sep;23(3):237-45. PubMed
  44.  
  45. Padurariu M, Ciobica A, Dobrin I, Stefanescu C. Evaluation of antioxidant enzymes activities and lipid peroxidation in schizophrenic patients treated with typical and atypical antipsychotics. Neurosci Lett. 2010 Aug 2;479(3):317-20. CrossRef PubMed
  46.  
  47. Ciobica A, Padurariu M, Hritcu L. The effects of short-term nicotine administration on behavioral and oxidative stress deficiencies induced in a rat model of Parkinson's disease. Psychiatr Danub. 2012 Jun;24(2):194-205. PubMed
  48.  
  49. Padurariu M, Ciobica A, Hritcu L, Stoica B, Bild W, Stefanescu C. Changes of some oxidative stress markers in the serum of patients with mild cognitive impairment and Alzheimer's disease. Neurosci Lett. 2010 Jan 18;469(1):6-10. CrossRef PubMed
  50.  
  51. Gurzu C, Artenie V, Hritcu L, Ciobica A. Prenatal testosterone improves the spatial learning and memory by protein synthesis in different lobes of the brain in the male and female rat. Cent Eur J Biol. 2008, 3(1): 39-47. CrossRef  
  52. Alin Ciobica, Lucian Hritcu, Veronica Nastasa, Manuela Padurariu, Walther Bild, Inhibition of central angiotensin converting enzyme exerts anxiolytic effects by decreasing brain oxidative stress. J Med Biochem. 2011, 30(2): 109–114. CrossRef  
  53. Hritcu L, Ciobica A, Gorgan L., Nicotine-induced memory impairment by increasing brain oxidative stress. Cent. Eur. J. Biol. 2009; 4(3):335-342. CrossRef  
  54. Ciobica A, Hritcu L, Padurariu M, Dobrin R, Bild V. Effects of serotonin depletion on behavior and neuronal oxidative stress status in rat: relevance for anxiety and affective disorders. Adv Med Sci. 2010;55(2):289-96. CrossRef PubMed
  55.  
  56. Bild W, Hritcu L, Stefanescu C, Ciobica A. Inhibition of central angiotensin II enhances memory function and reduces oxidative stress status in rat hippocampus. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jun 3;43:79-88. CrossRef PubMed

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2019.