Українська English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2014; 60(2): 102-109

THE EFFECT OF MELATONIN ON BONE TISSUE METABOLISM

Litovka IH, Mazepa-Kryzhanivs'ka YO, Berezovskyĭ VIa.

    O.O.Bogomoletz Institute of Physiology, National Academy of Science of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz60.02.102


Abstract

In a review of the current literature for the 2000–2013 period, the data of the effect of melatonin on organic and inorganic І.Г. Літовка, У.О. Мазепа-Крижанівська, В.Я. Березовський 108 ISSN 0201-8489 Фізіол. журн., 2014, Т. 60, № 2 matrix of bone tissue have been presented. These results suggest that melatonin is an important mediator in the formation of bone tissue. It can prevent the premature destruction of bone and promote its recovery through mechanisms of melatoninrelated receptors and receptors of independent action.

Keywords: melatonin, tissue bone

Full text: (PDF, in Ukrainian)

References

  1. Bogomolets A.A. Connective tissue physiological system and affect its function antireticular cytotoxic serum. Physiological system of connective tissue. Kiev: Academy of Sciences of the USSR, 1941. P.23-62.
    2.  
  2. Bogomolets A.A. Selected Works. K.: Science opinion, 1969. 422 p.
    3.  
  3. Podrushnyak E.P. Age-related changes and diseases of the human musculoskeletal system. K.: Health, 1987. 304 p.
    4.  
  4. Cardinali D.P., Ladizesky M.G., Boggio V., Cutrera R.A., Mautalen C. Melatonin effects on bone: experimental facts and clinical perspectives J. of Pineal Research. 2003; 34 (2): 81-87. CrossRef  
  5. Fernández-Tresguerres Hernández-Gil I., Alobera-Gracia M. A., Mariano C. P., Jerez L. B. Physiological bases of bone regeneration II. The remodeling process Med. Oral. Patol. Oral. Cir. Bucal. 2006; 1: 151-157.
    6.  
  6. Markus R.P., Cecon E., Pires-Lapa M.A. Immune-Pineal Axis: Nuclear Factor κB (NF-kB) Mediates the Shift in the Melatonin Source from Pinealocytes to Immune Competent Cells. Int. J. Mol. Sci. 2013; 14 (10): 10979- 10997. CrossRef PubMed PubMedCentral
    7.  
  7. Ohlsson C., Bengtsson B., Isaksson Olle G. Growth Hormone and Bone Endocrine Reviews. 1998; 19 (1): 55-79. PubMed
    8.  
  8. Zofková I. Neuro-skeletal biology and its importance for clinical osteology. Cesk Fysiol. 2012; 61 (2): 41-44. PubMed
    9.  
  9. Sanchez-Barcelo E.J., Mediavilla M.D., Tan D.X., Reiter R.J. Scientific basis for the potential use of melatonin in bone disease: osteoporosis and adolescent idiopathic scoliosis. J. of Osteoporosis. 2010; 2010 (1): 1-10. CrossRef PubMed PubMedCentral
    10.  
  10. Wolden-Hanson T., Mitton D. R., MCCants R. L., Yellon S. M., Wilkinson C. W., MatsumotoA. M., Rasmussen D. D. Daily melatonin administration to middle-Aged Male Rats Suppresses Body Weight, Intraabdominal Adiposity, and plasma leptin and insulin independent of food intake and total body fat. Endocrinology. 2000; 41 (2): 487-497. CrossRef PubMed
    11.  
  11. Kvetnoy I.M., Reichlin N.T., Yuzhakov V.V., Ingel I.E. Ekstrapinealny melatonin: the place and role in the neuroendocrine regulation of homeostasis. BEBiM . 1999; 127 (4): 364 370.
    12.  
  12. Anisimov V.N. Melatonin role in the body, the application in the clinic. St. Petersburg: Publisher «System», 2007. 40 p.
    13.  
  13. Ostrowska Z, Kos-Kudla B, Nowak M, Swietochowska E, Marek B, Gorski J, Kajdaniuk D, Wolkowska K. The relationship between bone metabolism, melatonin and other hormones in sham-operated and pinealectomized rats. Endocr. Regul. 2003; 37 (4): 163-174. PubMed
    14.  
  14. Cutando A, Gómez-Moreno G, Arana C, Acu-a-Castroviejo D, Reiter RJ. Melatonin: potential functions in the oral cavity. J Periodontol. 2007; 78 (6): 1094-1102. CrossRef PubMed
    15.  
  15. Ostrowska Z, Wołkowska-Pokrywa K, Kos-Kudła B, Swietochowska E, Marek B, Kajdaniuk D. Melatonin and bone status. Pol. Merkur. Lekarski. 2006; 21 (124): 389-93.
    16.  
  16. Ostrowska Z., Kos-Kudla K., Marek B. et al. The relationship between the daily profile of chosen biochemical markers of bone metabolism and melatonin and other hormones secretion in rats under physiological conditions. Neuroendocrinol. Lett. 2002; 23 (5-6): 417- 425. PubMed
    17.  
  17. Shinoda H., Stern P.H. Diurnal rhythms in Ca transfer into bone, Ca release from bone, and bone resorbing activity in serum of rats. Amer. J. Physiol. Regul. Integr. Comp. Physiol.1992: 262 (2): R.235 R.240.
    18.  
  18. Sirotinin N.N. Effect of adaptation to hypoxia and acclimatization to high mountain climate on the resistance of animals to some extreme effects. Patol. Physiol. Exp. Ter. 1964; 33: 12-15.
    19.  
  19. Shao P., Ohtsuka-Iso Y.A., Shinoda H. Circadian rhythms in serum bone markers and the relation to the effect of etidronate in rats. Chronobiol. Int. 2003; 20 (2): 325- 326. CrossRef PubMed
    20.  
  20. Reiter R. J., Tan D.-X., Manchester L. C., Qi W. Biochemical reactivity of melatonin with reactive oxygen and nitrogen species: a review of the evidence. Cell Biochemistry and Biophysics. 2001; 34 (2): 237-256. CrossRef  
  21. Witt-Enderby P.A., Slater J.P., Johnson N.A., Bondi C.D., Dodda B.R., Kotlarczyk M.P., Clafshenkel W.P., Sethi S., Higginbotham S., Rutkowski J.L., Gallagher K.M., Davis V.L. Effects on bone by the light/dark cycle and chronic treatment with melatonin and/or hormone replacement therapy in intact female mice. J Pineal Res. 2012; 53 (4): 374-384. CrossRef PubMed
    22.  
  22. Berezovskii V.A., Litovka I.G., Veselskii S.P., Zamorska T.M., Yanko R.V. The exogenous melatonin influence on the bone`s organic matrix lipid and amino acid. Space Science and Technology. 2012; 18 (3): 78-82.
    23.  
  23. Karasek M. Melatonin, human aging, and age-related diseases. Experimental Gerontology. 2004; 39 (11-12): 1723-1729. CrossRef PubMed
    24.  
  24. Man G.C., Wong J.H., Wang W.W., Sun G.Q. et al. Abnormal melatonin receptor 1B expression in osteoblasts from girls with adolescent idiopathic scoliosis. J. Pineal Res. 2011; 50 (4): 395-402. CrossRef PubMed
    25.  
  25. Egermann M., Gerhardt C., Barth A., Maestroni G.J., Schneider E., Alini M. Pinealectomy affects bone mineral density and structure--an experimental study in sheep. BMC Musculoskelet Disord. 2011; 24 (12): 271-280. CrossRef PubMed PubMedCentral
    26.  
  26. Kono H., Machida M., Saito M., Nishiwaki Y., Kato H., Hosogane N., Chiba K., Miyamoto T., Matsumoto M., Toyama Y. Mechanism of osteoporosis in adolescent idiopathic scoliosis: experimental scoliosis in pinea lectomized chickens. J Pineal Res. 2011; 51 (4): 387-393. CrossRef PubMed
    27.  
  27. Machida M., Dubousset J., Yamada T. Experimental scoliosis in melatonin-deficient C57BL/6J mice without pinealectomy. J. of Pineal Research. 2006; 41 (1): 1-7. CrossRef PubMed
    28.  
  28. Oyama J., Murai I., Kanazawa K., Machida M. Bipedal ambulation induces experimental scoliosis in C57BL/6J mice with reduced plasma and pineal melatonin levels. J. of Pineal Research. 2006; 40 (3): 219-224. CrossRef PubMed
    29.  
  29. Hakanson D. O., Bergstrom W. H. Phototherapyinduced hypocalcemia in newborn rats: prevention by melatonin. Science. 1981; 214 (4522): 807-809. CrossRef  
  30. Hakanson D. O., Penny R., Bergstrom W. H. Calcemic responses to photic and pharmacologic manipulation of serum melatonin. Pediatric Research. 1987; 22 (4): 414-416. CrossRef PubMed
    31.  
  31. Roth J. A., Kim B.-G., Lin W.-L., Cho M.-I. Melatonin promotes osteoblast differentiation and bone formation. J. of Biological Chemistry. 1999; 274 (31): 22041-22047. CrossRef  
  32. Sanchez-Hidalgo M., Lu Z.,Tan D.-X, Maldonado M. D., Reiter R.J., Gregerman R.I. Melatonin inhibits fatty acid-induced triglyceride accumulation in ROS17/2.8 cells: implications for osteoblast differentiation and osteoporosis. Am. J. of Physiology. 2007; 292 (6): R2208-R2215. CrossRef  
  33. Zaminy A., Kashani I. R., Barbarestani M., Hedayatpour A. et al. Osteogenic differentiation of rat mesenchymal stem cells from adipose tissue in comparison with bone marrow mesenchymal stem cells: melatonin as a differentiation factor. Iranian Biomedical Journal. 2008; 12 (3): 133-141. PubMed
    34.  
  34. Zaminy A., Kashani I., Barbarestani M. et al. Effects of melatonin on the proliferation and differentiation of rat adipose-derived stem cell. Indian Journal of Plastic Surgery. 2008; 41 (1): 8-14. CrossRef PubMed PubMedCentral
    35.  
  35. Nakade O., Koyama H., Ariji HYajima., A., Kaku T. Melatonin stimulates proliferation and type I collagen synthesis in human bone cells in vitro. J. of Pineal Research. 1999; 27 (2): 106-110. CrossRef  
  36. Satomura K., Tobiume S., Tokuyama R. et al. Melatonin at pharmacological doses enhances human osteoblastic differentiation in vitro and promotes mouse cortical bone formation in vivo. J. of Pineal Research. 2007; 42 (3): 231-239. CrossRef PubMed
    37.  
  37. Radio N.M., Doctor J. S., A.Witt-Enderby P. Melatonin enhances alkaline phosphatase activity in differentiating human adult mesenchymal stem cells grown in osteogenic medium via MT2 melatonin receptors and the MEK/ERK (1/2) signaling cascade. J. of Pineal Research. 2006; 40 (4): 332-342. CrossRef PubMed
    38.  
  38. Fraser J. H. E., Helfrich M. H., Wallace H. M., Ralston S. H. Hydrogen peroxide, but not superoxide, stimulate bone resorption in mouse calvariae. Bone 1996; 19 (3): 223-226. CrossRef  
  39. Reiter R.J., Paredes S.D., Manchester L.C., Tan D.X. Reducing oxidative/nitrosative stress: a new discovered genre for melatonin. Critical Reviews in Biochemistry and Molecular Biology. 2009; 44 (2): 175-200. CrossRef PubMed
    40.  
  40. Suzuki N. Hattori A. Melatonin suppresses osteoclastic and osteoblastic activities in the scales of goldfish. J. of Pineal Research. 2002; 33 (4): 253-258. CrossRef PubMed
    41.  
  41. Conconi S., Hertens E., Skwarlo-Sonta K., Markowska M., Maestroni G.J.M. Evidence for melatonin synthesis in mouse and human bone marrow cells. J.of Pineal Research. 2000; 28 (4): 193-202. CrossRef PubMed
    42.  
  42. Schroeder A., Van Der Zypen E., Stich H., Sutter F. The reactions of bone, connective tissue, and epithelium to endosteal implants with titanium-sprayed surfaces.J. of Maxillofacial Surgery. 1981; 9 (1): 15-25. CrossRef  
  43. Penarrocha Diago M., Oltra Moscardo M.J., Sanchis Bielsa J.M. Implantologia Oral. Barcelona, Spain: Ars Medica; 2005. Conceptos generales de implantologia. 3-17.
    44.  
  44. Steflik D.E., Parr G.R., Sisk A.L. et al. Osteoblast activity at the dental implant-bone interface: transmission electron microscopic and high voltage electron microscopic observations. J. of Periodontology. 1994; 65 (5): 404-413. CrossRef PubMed
    45.  
  45. Lissoni P., Barni S., Cattaneo G. Clinical results with the pineal hormone melatonin in advanced cancer resistant to standard antitumor therapies. Oncology. 1991; 48 (6): 448-450. CrossRef PubMed
    46.  
  46. Krane S. M. Genetic control of bone remodeling-insights from a rare disease. New England Journal of Medicine. 2002; 347 (3): 210-212. CrossRef PubMed
    47.  
  47. Koyama H., Nakade O., Takada Y., Kaku T., Lau K.-H.W. Melatonin at pharmacologic doses increases bone mass by suppressing resorption through down-regulation of the RANKL-mediated osteoclast formation and activation/ J. of Bone andMineral Research. 2002; 17 (7): 1219-1229. CrossRef PubMed
    48.  
  48. Berezovskiy V.A., Litovka I.G., Kostjuchenko A.S., Yanko R.V.Influence of melatonin on the bone tissue physiological regeneration processes of young and adult rats. Space Science and Technology. 2008; 14 (3): 75-81. CrossRef  
  49. Liu X., Gong Y., Xiong K., Ye Y., Xiong Y., Zhuang Z., Luo Y., Jiang Q., He F. Melatonin mediates protective effects on inflammatory response induced by interleukin-1 beta in human mesenchymal stem cell. J. Pineal Res. 2013; 54 (1): 67-72. CrossRef  
  50. Magri F., Sarra S., Cinchetti W. Qualitative andquantitative changes of melatonin levels in physiological and pathological aging and in centenarians. J. of Pineal Research. 2004; 36 (4): 256-261. CrossRef PubMed
    51.  

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.