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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2001; 47(5): 3-11


L.g. stepanenko arginase inhibitors as a new class of antihypertension drugs:action of urea on oxidative metabolism of lipids at chronic hypertension

V.F. Sagach, A.V. Kotsuruba, O.V. Basilyuk, E.F. Meged, O.M. Buchanevich, N.M. Gulaya

    A.A.Bogomolets Institute of physiology NationalAcademy of Science of Ukraine, Kiеv;A.V.Palladin Institute of biochemistry NationalAcademy of Science of Ukraine, Kiеv


Abstract

Have studied action of chronic urea — an arginase inhibitor — introduction (40 mg/kg, 28 days) on blood pressure, endothelium-dependent reactions of aorta smooth muscle cells (SMС) and nonenzymatic (contents of diene conjugates and H2O2) and enzymatic (contents of free arachidonic acid and vasoconstrictic eicosanoids LTC4 and TXA2) oxidizing lipid meta- bolism of heart, aorta, plasma and erythrocytes of spontaneously hypertensive rats. Have shown, that urea down regulate blood pressure without any nor- malization of endothelium-dependent reactions of SMС of aorta and down regulate both enzymatic and non- enzymatic oxidizing lipid metabolism. Down regu- lation of two alternative (by cyclooxygenase and by lipoxygenase) enzymatic pathways of free arachidonic acid oxidizing metabolism by urea can be one of mecha- nisms of its antihypertensiv action. The posibility of urea use at hypertension and various pathophysiological conditions are discussed

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