EFFECT OF NMDA-RECEPTOR BLOCKERS ON THE DYNAMICS OF INTRAOCULAR PRESSURE IN RABBITS
I.L. Chereshnyuk, O.I. Alchuk, L.I. Marynych, R.A. Kravets, A.O. Ivanitsa, O.A. Khodakovskyi
Vinnytsya National Medical University n.a. M.I. Pyrogov
DOI: https://doi.org/10.15407/fz63.01.069
Abstract
Experiments on rabbits with a model of acute temporary ocular
hypertension created by intragastric administration of water
(100 ml/kg) have been performed. It was found that intravenous
administration or instillation into the eye of blocker
of NMDA-receptor 1-adamantylethyloxy-3-morpholino-2-
propanol hydrochloride (Ademol) unlike amantadine sulfate
results in a significant decrease in intraocular pressure (IOP).
It was also discovered that such ocular hypotensive effect
takes place in animals with unchanged ophthalmotonus. Taking
into account neuroretinoprotective and hypotensive ocular
hypotensive properties of Ademol this drug appears to be perspective
in the treatment of ischemic disorders of the retina and
optic nerve, especially under the conditions of increased IOP.
Keywords:
ademol; amantadine sulfate; NMDA-receptors; intraocular pressure; neuroretinoprotection.
References
- Osborne NN. Pathogenesis of ganglion «cell death» in glaucoma and neuroprotection: focus on ganglion cell axonal mitochondria. Prog Brain Res. 2008;173:339-52.
CrossRef
- Chi W, Li F, Chen H, Wang Y, Zhu Y et al. Caspase-8 promotes NLRP1/NLRP3 inflammasome activation and IL-1β production in acute glaucoma. Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11181-6.
CrossRef
- Ha Y, Liu H, Xu Z, Yokota H, Narayanan SP et al. Endoplasmic reticulum stress-regulated CXCR3 pathway mediates inflammation and neuronal injury in acute glaucoma. Cell Death Dis. 2015 Oct 8;6:e1900.
CrossRef
- Zavgorodnyaya NG, Pasechnikova NV. Primary glaucoma. A new look at an old problem. Zaporozh'e: Orbita-YuG, 2010. [Ukrainian].
- Kasimova MS. The comparative analysis of a an anterior ischemic optical neuropathy and glaucoma optical neuropathy. Glaucoma. 2010;9(3):50-54. [Russian].
- Osborne NN, DeSantis L, Bae JH, Ugarte M, Wood JP, Nash MS et al. Topically applied betaxolol attenuates NMDAinduced toxicity to ganglion cells and the effects of ischaemia to the retina. Exp Eye Res. 1999 Sep;69(3):331-42.
CrossRef
- Ebneter A, Chidlow G, Wood JP, Casson RJ. Protection of retinal ganglion cells and the optic nerve during short-term hyperglycemia in experimental glaucoma. Arch Ophthalmol. 2011 Oct;129(10):1337-44.
CrossRef
- Nilforushan N. Neuroprotection in glaucoma. J Ophthalmic Vis Res. 2012 Jan;7(1):91-3.
- Ullian EM, Barkis WB, Chen S, Diamond JS, Barres BA. Invulnerability of retinal ganglion cells to NMDA excitotoxicity. Mol Cell Neurosci. 2004 Aug;26(4):544-57.
CrossRef
- Harada T, Harada C, Nakamura K, Quah HA, Okumura A, Namekata K et al. The potential role of glutamate transporters in the pathogenesis of normal tension glaucoma. J Clin Invest. 2007 Jul;117(7):1763-70.
CrossRef
- Gabelt BT, Rasmussen CA, Tektas OY, Kim CB, Peterson JC, Nork TM et al. Structure/function studies and the effects of memantine in monkeys with experimental glaucoma. Invest Ophthalmol Vis Sci. 2012 Apr 30;53(4):2368-76.
CrossRef
- Shih GC, Calkins DJ. Secondary neuroprotective effects of hypotensive drugs and potential mechanisms of action. Expert Rev Ophthalmol. 2012 Apr;7(2):161-175.
CrossRef
- Khodakivskyi OA. Pathogenetic background of new adamantane derivatives use reasonability in brain and myocardial acute ischemia experimental therapy (experimental investigation) [dissertation]. Odessa: Odessa National Med Univ Minist Health Care Ukr; 2014. [Ukrainian].
- Kovtunenko VO. Medicines with action on the peripheral nervous system. Kiev, 2005. [Ukrainian].
- Skvortsova MI, Stankevich IV, Palyulin VA, Zefirov NS. Molecular similarity concept and its use for prediction of the properties of chemical compounds. Uspekhi khimii. 2006;75(11):1074-93. [Russian].
CrossRef
- Calculation of Molecular Properties and Bioactivity Score. Molinspiration Cheminformatics, 2012. Available from: http://www.molinspiration.com/cgi-bin/properties.
- Mishra NK, Kumar M, Raghava GP. Support vector machine based prediction of glutathione S-transferase proteins. Protein Pept. Lett. 2007;14(6):575-80.
CrossRef
- Nisoli E, Tonello C, Landi M, Carruba MO. Functional studies of the first selective β3-adrenergic receptor antagonist SR 59230A in rat brown adipocytes. Mol. Pharmacol. 1996;49(1):7-14.
- Kaiser HJ, Flammer J, Stümpfig D, Hendrickson P. Longterm visual field follow-up of glaucoma patients treated with beta-blockers. Surv Ophthalmol. 1994 May;38 Suppl:S156-9; discussion S160.
- De Simone FI, Serratosa J. Biotechnology, animal health and animal welfare within the framework of European Union legislation. Rev Sci Tech. 2005 Apr;24(1):89-99.
CrossRef
- van Bijsterveld OP, van Loenen AC, ten Ham M. The effect of hypotensive drugs on the intraocular pressure after waterloading in rabbits. Doc Ophthalmol. 1981 Dec;52(2):189-98.
CrossRef
- Bar-Ilan A. Diurnal and seasonal variations in intraocular pressure in the rabbit. Exp Eye Res. 1984 Aug;39(2):175-81.
CrossRef
- Bar-Ilan A, Beilin M. Diurnal variations in intraocular pressure in the albino rabbit: relationship to morning intraocular pressure. Ophthalmic Res. 1997;29(2):110-6.
CrossRef
- Gabelt BT, Rasmussen CA, Tektas OY, Kim CB, Peterson JC, Nork TM et al. Structure/function studies and the effects of memantine in monkeys with experimental glaucoma. Invest Ophthalmol Vis Sci. 2012 Apr 30;53(4):2368-76.
CrossRef
- Osborne NN, Wood JP, Melena J, Chao HM, Nash MS, Bron AJ et al. 5-Hydroxytryptamine1A agonists: potential use in glaucoma. Evidence from animal studies. Eye (Lond). 2000 Jun;14:454-63.
CrossRef
|