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Kinetics of absorption by the bovine retina of 1-14c-gabaand its b-vitamins preparations
Z.O.rozanova
Institute of Eye Diseases and Tissue Therapynamed by Filatov, AMS of Ukraine, Odessa
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Abstract
Absorption by the bovine retina of physiological con-
centration of PLP-GABA increase clearing 2-32 mi-
nutes of incubation in difference of GABA and its
non metabolic preparations, which store up as much
as possible in first minutes: picamilon > PLP-GABA
> GABA > panthogam > biotinil – GABA. Kinetics
of transport of GABA and its preparations into retina
has a complex character. By the growth of concen-
tration from 33 мM to 528 мM, it is linear for pica-
milion, showing diffusion, and not linear for GABA,
PLP-GABA and panthogam, showing differently sys-
tems of its transport. And only GABA transport is
activated by Na-ions.
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