CHANGES IN THE BRAIN TESTOSTERONE METABOLISM AND SEXUAL BEHAVIOR IN MALE RATS PRENATALLY EXPOSED TO METHYLDOPA AND STRESS
A.G. Reznikov, N.D. Nosenko, L.V. Tarasenko, A.A. Limareva
State Institution “V.P. Komissarenko Institute of
Endocrinology and Metabolism of National Academy of
Medical Sciences of Ukraine”, Kyiv
The changes of aromatase and 5α-reductase activities were
studied in preoptic area (POA) and medial basal hypothalamus
of 10-days-old and sexual behavior in 3-month-old male
offsprings of rats exposed daily to noradrenaline antagonist
methyldopa (400 mg/kg per os) 30 minutes prior to 1-hour
immobilization during the last week of pregnancy (from 15th to
21st day). Prenatal stress caused aromatase activity lowering in
the POA of developing brain and feminization (appearance of
lordosis) and demasculinization of sexual behavior (prolongation
of latent periods to the first mounting and first intromission
as well as of the first ejaculation and postejaculation refractory
period) in young male offspring. Oral methyldopa used prior
to pregnant females stressing prevented early effect of prenatal
stress on aromatase activity in the POA and normalized the
male sexual behavior in young male rats by shortening both
latent period to the first ejaculation and postejaculation refractory
period, and an increase of numbers of ejaculation. The
data obtained indicate that brain noradrenergic system plays
significant role in the mechanisms of metabolic and behavioral
disturbances developing in male rats exposed to prenatal stress.
prenatal stress; methyldopa; testosterone metabolism; sexual behavior; male rats.
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