PARTISIPATION OF PARASYMPATHETIC PART OF NERVOUS SYSTEM IN REALIZATION OF BIOFLAVONOIDS ACTION ON GASTRIC SECRETION IN RATS
T.V. Vovkun1, P.I. Yanchuk1, L.Y. Shtanova1, S.P. Vesеlskyу1, A.S. Shalamaу2
- Kyiv Taras Shevchenko National University;
- Closed Joint Stock Company «Borschagovsky ChemicalPharmaceutical
Plant «, Kyiv, Ukraine
In this study we investigated the effects of corvitin – modified
form of flavonoid quercetin on the stomach secretory function
and physiological mechanisms involved in the maintenance of
such effects in rat’s pylorus-ligated model. In animals which
corvitin was injected at a dose of 5 mg/kg, regardless of the
route of administration – in the stomach or duodenum, did not
observe any changes in the volume of gastric juice or general
production of hydrochloric acid, compared with the control
data. Dose of 40 mg/kg caused an increase in the volume of
gastric juice and hydrochloric acid output as when administered
in the stomach and in the duodenum. We also found that
after the application of a large dose of corvitin (intragastrically)
in the blood of experimental animals showed reduction in
glucose levels, which was not detected when using the drug
in a dose of 5 mg/kg. Nonspecific antagonist of M-cholinergic
receptors – atropine almost completely blocked the enhancement
of gastric secretion, which was caused by the introduction
into the stomach of corvitin in large dose. From the present
data, it is reasonable to conclude that intragastric administration
of a large dose of corvitin to pylorus-ligated rats induces
hypoglycemic reaction of blood, which may causes an increase
in vagus nerve activity with subsequent stimulation of gastric
secretion. The increase in gastric juice volume and gastric
acid output induced by corvitin was completely inhibited by
atropine. These results suggested that the increase in gastric
secretion induced by intragastrically administered corvitin
could be mediated by the parasympathetic nervous system.
stomach, corvitin, hypoglycemia, gastric secretion, hydrochloric acid, parasympathetic nervous system, pylorus ligation.
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