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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2015; 61(1): 50-55


PARTISIPATION OF PARASYMPATHETIC PART OF NERVOUS SYSTEM IN REALIZATION OF BIOFLAVONOIDS ACTION ON GASTRIC SECRETION IN RATS

T.V. Vovkun1, P.I. Yanchuk1, L.Y. Shtanova1, S.P. Vesеlskyу1, A.S. Shalamaу2

  1. Kyiv Taras Shevchenko National University;
  2. Closed Joint Stock Company «Borschagovsky ChemicalPharmaceutical Plant «, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz61.01.050

Abstract

In this study we investigated the effects of corvitin – modified form of flavonoid quercetin on the stomach secretory function and physiological mechanisms involved in the maintenance of such effects in rat’s pylorus-ligated model. In animals which corvitin was injected at a dose of 5 mg/kg, regardless of the route of administration – in the stomach or duodenum, did not observe any changes in the volume of gastric juice or general production of hydrochloric acid, compared with the control data. Dose of 40 mg/kg caused an increase in the volume of gastric juice and hydrochloric acid output as when administered in the stomach and in the duodenum. We also found that after the application of a large dose of corvitin (intragastrically) in the blood of experimental animals showed reduction in glucose levels, which was not detected when using the drug in a dose of 5 mg/kg. Nonspecific antagonist of M-cholinergic receptors – atropine almost completely blocked the enhancement of gastric secretion, which was caused by the introduction into the stomach of corvitin in large dose. From the present data, it is reasonable to conclude that intragastric administration of a large dose of corvitin to pylorus-ligated rats induces hypoglycemic reaction of blood, which may causes an increase in vagus nerve activity with subsequent stimulation of gastric secretion. The increase in gastric juice volume and gastric acid output induced by corvitin was completely inhibited by atropine. These results suggested that the increase in gastric secretion induced by intragastrically administered corvitin could be mediated by the parasympathetic nervous system.

Keywords: stomach, corvitin, hypoglycemia, gastric secretion, hydrochloric acid, parasympathetic nervous system, pylorus ligation.

References

  1. Ravichandran R, Rajendran M, Devapiriam D. Antioxidant study of quercetin and their metal complex and determination of stability constant by spectrophotometry method. Food Chem. 2014;146:472–8. CrossRef PubMed
  2.  
  3. Beil W, Birkholz C, Sewing KF. Effects of flavonoids on parietal cell acid secretion, gastric mucosal prostaglandin production and Helicobacter pylori growth. Arzneimittelforschung. 1995;45(6):697–700.
  4.  
  5. Min YS, Lee SE, Hong ST, Kim HS, Choi B-C, Sim SS, Whang WK, Sohn UD. The Inhibitory Effect of Quercetin-3-O-β-D-Glucuronopyranoside on Gastritis T.V. Vovkun, P.І. Yanchuk, L.Ya. SHtanova, S.P. Vesel's'kii, a.S. SHalamai and Reflux Esophagitis in Rats. Korean J Physiol Pharmacol. 2009;13:295–300. CrossRef PubMed PubMedCentral
  6.  
  7. Choi EJ, Chee KM, Lee BH. Anti- and prooxidant effects of chronic quercetin administration in rats. Eur J Pharmacol. 2003;482(1-3):281–85.
  8.  
  9. Murota K, Terao J. Antioxidative flavonoid quercetin: implication of its intestinal absorption and metabolism. Arch Biochem Biophys. 2003;417:12–17. CrossRef  
  10. Kesarwani K, Gupta R, Mukerjee A. Bioavailability enhancers of herbal origin: an overview. Asian Pac J Trop Biomed. 2013;4:253–66. CrossRef  
  11. Sahoo NG, Kakran M, Shaal LA, Li L, Muller RH, Pal M, Tan LP. Preparation and characterization of quercetin nanocrystals. J Pharm Sci. 2011;100(6):2379–90. CrossRef PubMed
  12.  
  13. Mokhort NA, Shalamay AS, Frantsuzova SB. Study of pharmacotherapeutic properties dosage forms of quercetin. In: Moibenko AA. Bioflavonoids as organoprotectors (quercetin, corvitin, quertin). Kiev: Naukova Dumka; 2012. – r. 74–117. [Ukrainian].
  14.  
  15. Vovkun TV, Yanchuk PI, Shtanova LY, Veselskiy SP, Baranowskiy VA. Effect of Corvitin on secretory processes and blood flow in the gastric mucosa of rats. Physiol Zh. 2013;59(1): 40–7. [Ukrainian].
  16.  
  17. Tetyana V. Vovkun, Petro I. Yanchuk, Lydia Y. Shtanova, Stanislav P. Veselsky, Vasyl A. Baranowskyy. Effect of Corvitin on Secretory Processes and Blood Flow in the Rat Gastric Mucosa. Int J Physiol and Pathophysiol. 2014;i4.70(4):335-43.
  18.  
  19. Shay H, Komarov S, Fels SS, Meranze D, Gruenshtein M, Siplet H. A simple method for the uniform production of gastric ulceration in the rat. Gastroenterol. 1945;5:43–61.
  20.  
  21. Hakanson R, Hedenbro J, Liedberg G, Sundler F, Vallgren S. Mechanisms of gastric acid secretion after pylorus and oesophagus ligation in the rat. J Physiol. 1980;305:139–49. CrossRef PubMed PubMedCentral
  22.  
  23. Furutani K, Aihara T, Nakamura E, Tanaka S, Ichikawa A, Ohtsu H, Okabe S. Crucial Role of Histamine for Regulation of Gastric Acid Secretion Ascertained by Histidine Decarboxylase-Knockout Mice. The J of Pharm and Experim Ther. 2003;307:331–38. CrossRef PubMed
  24.  
  25. Kurasawa T, Chikaraishi Y, Naito A, Toyoda Y, Notsu Y. Effect of humulus lupulus on gastric secretion in a rat pylorus-ligated model. Biol Pharm Bull. 2005;28(2):353–57. CrossRef PubMed
  26.  
  27. Kovacs TO1, Lloyd KC, Walsh JH. Gastrin partially mediates insulin-induced acid secretion in dogs. Peptides. 1996;17(4):583–87. CrossRef  
  28. Polacek MA, Ellison EH. Insulin-Induced Stimulation of Gastric Acid Secretion. JAMA. 1963;183(12):1006–7.
  29.  
  30. Bardy G, Virsolvy A, Quignard JF, Ravier MA, Bertrand G, Dalle S, Cros G, Magous R, Richard S, Oiry C. Quercetin induces insulin secretion by direct activation of L-type calcium channels in pancreatic beta cells. Br J Pharmacol. 2013;169(5):1102–13. CrossRef PubMed PubMedCentral
  31.  
  32. Ojewole JA. Hypoglycemic effect of Sclerocarya birrea [(A. Rich.) Hochst.] [Anacardiaceae] stem-bark aqueous extract in rats. Phytomedicine. 2003;10(8):675–81.
  33.  

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