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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2015; 61(1): 50-55


T.V. Vovkun1, P.I. Yanchuk1, L.Y. Shtanova1, S.P. Vesеlskyу1, A.S. Shalamaу2

  1. Kyiv Taras Shevchenko National University;
  2. Closed Joint Stock Company «Borschagovsky ChemicalPharmaceutical Plant «, Kyiv, Ukraine


In this study we investigated the effects of corvitin – modified form of flavonoid quercetin on the stomach secretory function and physiological mechanisms involved in the maintenance of such effects in rat’s pylorus-ligated model. In animals which corvitin was injected at a dose of 5 mg/kg, regardless of the route of administration – in the stomach or duodenum, did not observe any changes in the volume of gastric juice or general production of hydrochloric acid, compared with the control data. Dose of 40 mg/kg caused an increase in the volume of gastric juice and hydrochloric acid output as when administered in the stomach and in the duodenum. We also found that after the application of a large dose of corvitin (intragastrically) in the blood of experimental animals showed reduction in glucose levels, which was not detected when using the drug in a dose of 5 mg/kg. Nonspecific antagonist of M-cholinergic receptors – atropine almost completely blocked the enhancement of gastric secretion, which was caused by the introduction into the stomach of corvitin in large dose. From the present data, it is reasonable to conclude that intragastric administration of a large dose of corvitin to pylorus-ligated rats induces hypoglycemic reaction of blood, which may causes an increase in vagus nerve activity with subsequent stimulation of gastric secretion. The increase in gastric juice volume and gastric acid output induced by corvitin was completely inhibited by atropine. These results suggested that the increase in gastric secretion induced by intragastrically administered corvitin could be mediated by the parasympathetic nervous system.

Keywords: stomach, corvitin, hypoglycemia, gastric secretion, hydrochloric acid, parasympathetic nervous system, pylorus ligation.


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